Osteoarthrosis Essay

Osteoarthrosis(OA), is a type of joint disease that results from the breakdown of joint cartilage and underlying bone.[1] The most commonly involved joints are those near the ends of the fingers, at the base of the thumb, neck, lower back, knees, and hips. Joints on one side of the body are often more affected than those on the other. It can affect work and normal daily activities. Unlike other types of arthritis, only the joints are typically affected.[2] This popularity in applying complementary and alternative medicine can be due to its advantages such as widespread availability, no or fewer side effects, moderate efficacy, and low cost as compared with synthetic drugs (Edraki et al. 2014, De Silva et al.2011, Ernst 2011). Treatment for …show more content…
Natural medicines derived from plant extracts are being increasingly utilized to treat a wide variety of clinical diseases, though relatively little knowledge about their mode of action is available [6] . So, there is also a need for the development of a potent analgesic without or with least side effects from plant sources. Psidium guajava is commonly known as guava. Psidium guajava is a medium sized tree belonging to the family Myrtaceae found throughout the tropics [7] . Psidium guajava is used traditionally for a number of ailments since a long time in history. The part of the plant used maximum is the leaves, followed by the fruits, bark and the roots. The traditional uses of the plant are [7] antidiarrheal, antimicrobial activity, dental plaque removal, antimalarial/antiparasitic activity, antitussive and antihyperglycemic. Leaves are used as Anti-inflammatory, analgesic and antinociceptive effects. Previous studies are there on antinociceptive action of leaves [8] . The aim of the study was to evaluate the treatment of OA of the knee hydroalcoholic extract of the leaf of Psidium guajava in rats, regarding radiological and histopathological