C3252
Description:
IC50: 7 nM
Neutrophil Elastase Inhibitor is a neutrophil elastase inhibitor.
Human neutrophil elastase (HNE) is a member of the chymotrypsin superfamily of serine proteases that is involved in the response to inflammatory stimuli. HNE is reported to be stored in azurophilic granules of neutrophils and is greatly aggressive and cytotoxic, as its substrates include various components of the extracellular matrix.
In vitro: Previous study found that Neutrophil Elastase Inhibitor was able to inhibit thrombin and urokinase at micromolar concentrations. In addition, Neutrophil Elastase Inhibitor appeared to be a specific HNE inhibitors in a competitive manner. Moreoer, the hydrolysis of the acyl−enzyme complex for Neutrophil
Description:
IC50: 7 nM
Neutrophil Elastase Inhibitor is a neutrophil elastase inhibitor.
Human neutrophil elastase (HNE) is a member of the chymotrypsin superfamily of serine proteases that is involved in the response to inflammatory stimuli. HNE is reported to be stored in azurophilic granules of neutrophils and is greatly aggressive and cytotoxic, as its substrates include various components of the extracellular matrix.
In vitro: Previous study found that Neutrophil Elastase Inhibitor was able to inhibit thrombin and urokinase at micromolar concentrations. In addition, Neutrophil Elastase Inhibitor appeared to be a specific HNE inhibitors in a competitive manner. Moreoer, the hydrolysis of the acyl−enzyme complex for Neutrophil