Neonatal sepsis is potentially fatal blood stream infection occurring in the first month of life.(1) Roughly, 1 million deaths for every year are brought on by sepsis happening in the neonatal period (0-28 days), accounting for over 25% of global neonatal deaths; 99% of these deaths occur in developing countries.(2) It is estimated that up to 20% of neonates develop sepsis and among them approximately 1% die of sepsis. Sepsis related mortality is largely preventable with prevention of sepsis, timely recognition, and rational antimicrobial therapy.(3)
Neonatal sepsis is confirmed by demonstrable growth of bacteria in cultures from a normally sterile site. This is most commonly blood cultures, but many authors include cultures from cerebrospinal fluid.(4)(5)(6)
Neonatal septicemia (sepsis) is divided into early-onset sepsis (EOS) and late-onset sepsis (LOS) according to the age of presentation. EOS reflects ascending infections from the maternal genital tract or transplacental infection, whereas LOS is associated with the postnatal nosocomial or community acquired sepsis, with the peak incidence reported to be between the 10th and 22nd day of life.(7)
It is necessary to know etiology (bacteria), risk factors and antimicrobial sensitivity pattern that cause neonatal sepsis in developing countries to develop effective …show more content…
The increasing number of multi-resistant strains is a serious matter of concern, especially in developing countries.(7) Higher mortality has been reported with neonatal sepsis due to extended-spectrum beta-lactamase (ESBL) producing Gram-negative bacilli (GNB).(8) The increased mortality is generally not to be due to increased disease severity in patients presenting with ESBL-positive sepsis, but rather due to higher rates of treatment
Neonatal sepsis is confirmed by demonstrable growth of bacteria in cultures from a normally sterile site. This is most commonly blood cultures, but many authors include cultures from cerebrospinal fluid.(4)(5)(6)
Neonatal septicemia (sepsis) is divided into early-onset sepsis (EOS) and late-onset sepsis (LOS) according to the age of presentation. EOS reflects ascending infections from the maternal genital tract or transplacental infection, whereas LOS is associated with the postnatal nosocomial or community acquired sepsis, with the peak incidence reported to be between the 10th and 22nd day of life.(7)
It is necessary to know etiology (bacteria), risk factors and antimicrobial sensitivity pattern that cause neonatal sepsis in developing countries to develop effective …show more content…
The increasing number of multi-resistant strains is a serious matter of concern, especially in developing countries.(7) Higher mortality has been reported with neonatal sepsis due to extended-spectrum beta-lactamase (ESBL) producing Gram-negative bacilli (GNB).(8) The increased mortality is generally not to be due to increased disease severity in patients presenting with ESBL-positive sepsis, but rather due to higher rates of treatment