When external antigen causes disease by infection, cell-mediated immune response in our body acts as basal defense system against exogenous pathogen. Native and adoptive immune system has established to attack infected cell by recognizing major histocompatibility complex (MHC). There are two major lymphocytes related to killing effect called cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells.[1], CTLs and NK cells recognize peptide epitope present on MHC class I to find infected cell. Especially, activated T cells are divided into effector T cell and memory T cell for effective defense system against secondary infection.[2] Cancer, which is classed as representative intractable disease, expresses TAA or mutated protein onto the surface of cancer cell. It also activates
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Nanomedicine can be accumulated at tumor site by enhanced permeability and retention time (EPR) effect, and thus is used in various clinical trials in the form of nano-formulation even in cancer immunotherapy.[7] Among various materials, hyaluronic acid (HA) has drawn tremendous attention owing to its superior biocompatibility and bio-degradability.[8] Furthermore, it can actively target tumor because of CD 44 receptor, as it has specific binding affinity with HA, which is over expressed on the surface of cancer cell followed by receptor-mediated endocytosis. Therefore, it might have great potential as an effective cancer therapeutic delivering formulation.
Theoretically, for being an effective cancer immunotherapeutic agent, three elements are vitally required: foreign antigen, immunologic adjuvant, and delivery technology. According to the backgrounds of this research as I mentioned so far, if that ideal agent can be formulated, it would be an innovative cancer immunotherapeutic agent, which could overcome the limitations of conventional
Nanomedicine can be accumulated at tumor site by enhanced permeability and retention time (EPR) effect, and thus is used in various clinical trials in the form of nano-formulation even in cancer immunotherapy.[7] Among various materials, hyaluronic acid (HA) has drawn tremendous attention owing to its superior biocompatibility and bio-degradability.[8] Furthermore, it can actively target tumor because of CD 44 receptor, as it has specific binding affinity with HA, which is over expressed on the surface of cancer cell followed by receptor-mediated endocytosis. Therefore, it might have great potential as an effective cancer therapeutic delivering formulation.
Theoretically, for being an effective cancer immunotherapeutic agent, three elements are vitally required: foreign antigen, immunologic adjuvant, and delivery technology. According to the backgrounds of this research as I mentioned so far, if that ideal agent can be formulated, it would be an innovative cancer immunotherapeutic agent, which could overcome the limitations of conventional