Myotonic Dystrophy Research Paper

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Myotonic dystrophy type 1 (DM1) or Steinert disease is a rare genetic multisystem disorder. Typical symptoms are delayed relaxation of muscles (myotonia) and slowly increased muscle weakness (dystrophy). It also affects the eye, heart, endocrine system, and central nervous system [1]. The prevelance is estimated at 1:10,000 [2]. DM1 is caused by an unstable (CTG) microsatellite repeat expansion within the DMPK (dystrophia myotonica protein kinase) 3- untranslated region (3’-UTR) in chromosome 19q13.3 [3]. Unaffected inidividuals contain 5-38 CTG repeats. Symptoms occur in individuals with more than 50 repeats. The length of extra repeats are proportional to the severity of the symptoms and disproportional to the age of onset [4]. There are

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