Mr Goodpasture

The relationship between Mr Goodpasture’s kidney disease and his medical history can be seen when looking at the risk factors and aetiology of kidney disease. The risk factors associated with chronic kidney disease specific to Mr Goodpasture are hypertension, tobacco smoking and alcohol consumption (Berman et al., 2012; LeMone et al., 2013). The aetiology of Mr Goodpasture’s end stage renal disease (ESRD) is due to his history of hypertension as seen in his medical history. His lifestyle factors of smoking and drinking alcohol may be the cause of his hypertension as they can lead to atherosclerosis (Berman et al., 2012; Bullock & Hales, 2013; LeMone et al., 2013). Prolonged hypertension leads to a high intra-glomerular pressure impairing glomerular …show more content…
This increases fluid volume and a subsequent further increase in blood pressure (Bullock & Hales, 2013; LeMone et al., 2013). Due to the increased pressure on the nephrons there is nephron loss (Bullock & Hales, 2013; LeMone et al., 2013). The remaining functioning nephrons hypertrophy and there is a subsequent increase in glomerular flow and pressure to compensate for the loss of nephrons (Bullock & Hales, 2013; LeMone et al., 2013). Eventually the remaining nephrons become non-functional due to focal glomerulosclerosis resulting in a severe loss of kidney function, called ESRD (Bullock & Hales, 2013; Berman et al., 2012; LeMone et al., 2013). ESRD is stage 5 where the GFR <15ml/min and either kidney transplant or dialysis is required to sustain life (Bullock & Hales, 2013; Berman et al., 2012; LeMone et al., 2013). Mr Goodpasture’s medical history of depression may be associated with his medical condition of ESRD (Bullock & Hales, 2013; Hardy, Kiernan, Kutscher, Cahill & Benvenisty, 2014; LeMone et al., 2013; Lew & Piraino,