Results:
Group A: mice from group A, showed normal features of skin, grossly it appeared as a thin and delicate layer, microscopically all of the components of mouse skin were thoroughly examined, including:
Epidermis: It was the outermost part of the skin composed of 3-4 sublayers. The stratum basale and stratum spinosum were prominent, while the stratum granulosum was often inapparent, it appeared as intermitten layer, keratohyalin granules were seen in some individual cells. The thickness of the stratum corneum was variable such as in some sections keratin materials were detached while in the others as a thin layer was remained. The epidermis in the control group was the thinnest layer which was about 6.9±0.05µm which made up 7% of the skin thickness.
Dermis: It was the second layer located under the epidermis which composed of densely packed, randomly oriented, thick bundles of collagen. Most of the skin appendages with exception of sweat …show more content…
The most prominent lesion in this layer was the formations of large number of epidermoid inclusion cysts with variable size ranged from to µm and forms (Capsulated and inflamed) which were formed as a result of degeneration in the hair follicles with associated sebaceous glands. Moreover, the dermis filled with inflammatory cells and implanted keratinocytes, the latter were participated in the formation of capsule of epidermal inclusion cysts. Histologically, capsulated cyst composed of concentric laminated keratin surrounded by stratified squamous epithelium or a thin layer of fibrosis. Whereas inflamed cyst composed keratin materials with a mixture of inflammatory cells, degenerative cells of hair follicles and sebaceous glands with implanted
Group A: mice from group A, showed normal features of skin, grossly it appeared as a thin and delicate layer, microscopically all of the components of mouse skin were thoroughly examined, including:
Epidermis: It was the outermost part of the skin composed of 3-4 sublayers. The stratum basale and stratum spinosum were prominent, while the stratum granulosum was often inapparent, it appeared as intermitten layer, keratohyalin granules were seen in some individual cells. The thickness of the stratum corneum was variable such as in some sections keratin materials were detached while in the others as a thin layer was remained. The epidermis in the control group was the thinnest layer which was about 6.9±0.05µm which made up 7% of the skin thickness.
Dermis: It was the second layer located under the epidermis which composed of densely packed, randomly oriented, thick bundles of collagen. Most of the skin appendages with exception of sweat …show more content…
The most prominent lesion in this layer was the formations of large number of epidermoid inclusion cysts with variable size ranged from to µm and forms (Capsulated and inflamed) which were formed as a result of degeneration in the hair follicles with associated sebaceous glands. Moreover, the dermis filled with inflammatory cells and implanted keratinocytes, the latter were participated in the formation of capsule of epidermal inclusion cysts. Histologically, capsulated cyst composed of concentric laminated keratin surrounded by stratified squamous epithelium or a thin layer of fibrosis. Whereas inflamed cyst composed keratin materials with a mixture of inflammatory cells, degenerative cells of hair follicles and sebaceous glands with implanted