2014, LaRocca, Hearon et al. 2014). Mitochondrial dysfunction can lead to severe damage in an organism. Several mitochondrial disorders present with neurological and muscular symptoms in the afflicted. In human patients with mutations in mtDNA or in nuclear genes coding for proteins in the mitochondrial ETC show multisystem disorders that include myopathy, stroke, and hearing loss (Liu and Rando 2011). A vast majority of research on why mitochondrial dysfunction gradually develops with time has focused on mtDNA integrity. Mutations and deletions in mtDNA increase with age, and areas of aged tissue that show mitochondrial ETC dysfunction contain abundant mtDNA damage (Xie, Lu et al. 2014). These findings and many earlier studies led to the concept that continuous accumulation of mtDNA damage may cause a role in the aging
2014, LaRocca, Hearon et al. 2014). Mitochondrial dysfunction can lead to severe damage in an organism. Several mitochondrial disorders present with neurological and muscular symptoms in the afflicted. In human patients with mutations in mtDNA or in nuclear genes coding for proteins in the mitochondrial ETC show multisystem disorders that include myopathy, stroke, and hearing loss (Liu and Rando 2011). A vast majority of research on why mitochondrial dysfunction gradually develops with time has focused on mtDNA integrity. Mutations and deletions in mtDNA increase with age, and areas of aged tissue that show mitochondrial ETC dysfunction contain abundant mtDNA damage (Xie, Lu et al. 2014). These findings and many earlier studies led to the concept that continuous accumulation of mtDNA damage may cause a role in the aging