Skin repair is an important physiological process that essential not only for homeostasis and restore barrier function, but also to …show more content…
There are many factors can affect wound healing such as age, smoking, diabetes, venous and arterial insufficiency in addition to the presence of resistance strain of microorganism(Garazi Gainza et al., 2015; Hajighasemali Davooda et al., 2016). Healing process involves interaction between different types of cells such as blood cell, fibroblast, epithelial cell and leukocyte (LeBert and Huttenlocher, 2014). Wound repair consists of four main stages that need to be organised to achieve proper skin tissue and restore protection from any opportunistic microorganisms(Thomas S. Lisse et al., 2016). These stages comprise platelet clot formation to re-established homeostasis, in addition to inflammation, tissue formation and remodeling to restore the internal or external of