I. INTRODUCTION
From the recent studies it has been known that breast cancer is the common occuring cancer among women in the worldwide. Metastasis is regarded to be as the main cause of death in breast cancer patients and reason for death around 90% of breast cancer are depicted because of local invasion and migration of tumor cells. Metastasis is defined as the spread of cancerous cells from the tumor site to the distance organs. It is a composite process that are divided into numerous steps comprising detachment of tumor cells from the origin site, invasion, migration, intravasation, survival in the vasculature, extravasation, and colonization of the secondary site (Ioannis et al.,2016; Pantel et al., 2004; Perou et al., 2000; Sotiriou …show more content…
Type 2 EMT is linked with wound healing and tissue regeneration, where tissue fibroblasts are regulated from epithelial cells throughout injury and chronic inflammation. Lastly Type 3 EMT takes place in epithelial cancer cells and implies cancer progression and metastasis. The three different categories symbolizes significantly diverse biological processes, where a few genetic fundamentals and mechanisms of regulation are …show more content…
It has also been reported that EMT is stimulated by external stimuli and microenvironment factors, which gives us a clue for plausible explanation for the de novo generation of CSCs from diff erentiated tumor cells that verifies that EMT serves as a driving force in tumorigenesis .Since metastatic breast cancer is a mystery and basically considered as an deadly disease, so a better survey and indepth study of EMT generation in the metastatic surge will lead to the progression of novel and promising targeted therapeutic
From the recent studies it has been known that breast cancer is the common occuring cancer among women in the worldwide. Metastasis is regarded to be as the main cause of death in breast cancer patients and reason for death around 90% of breast cancer are depicted because of local invasion and migration of tumor cells. Metastasis is defined as the spread of cancerous cells from the tumor site to the distance organs. It is a composite process that are divided into numerous steps comprising detachment of tumor cells from the origin site, invasion, migration, intravasation, survival in the vasculature, extravasation, and colonization of the secondary site (Ioannis et al.,2016; Pantel et al., 2004; Perou et al., 2000; Sotiriou …show more content…
Type 2 EMT is linked with wound healing and tissue regeneration, where tissue fibroblasts are regulated from epithelial cells throughout injury and chronic inflammation. Lastly Type 3 EMT takes place in epithelial cancer cells and implies cancer progression and metastasis. The three different categories symbolizes significantly diverse biological processes, where a few genetic fundamentals and mechanisms of regulation are …show more content…
It has also been reported that EMT is stimulated by external stimuli and microenvironment factors, which gives us a clue for plausible explanation for the de novo generation of CSCs from diff erentiated tumor cells that verifies that EMT serves as a driving force in tumorigenesis .Since metastatic breast cancer is a mystery and basically considered as an deadly disease, so a better survey and indepth study of EMT generation in the metastatic surge will lead to the progression of novel and promising targeted therapeutic