Malignant hyperthermia (MH) is a rare, inherited life-threatening condition that is induced by general anesthetic drugs such as halothane. Generally, most cases show no signs or symptoms until individuals are exposed to anesthesia. However, there are cases where an individual with MH goes under anesthetics and will not react. The reaction includes a dangerous rise in body temperature, metabolic and respiratory acidosis, hyperkalemia, and muscle rigidity. The response is due to an abnormal ryanodine receptor which is a Ca2+ release channel involved in excitation-contraction coupling. Normally, the
Malignant hyperthermia (MH) is a rare, inherited life-threatening condition that is induced by general anesthetic drugs such as halothane. Generally, most cases show no signs or symptoms until individuals are exposed to anesthesia. However, there are cases where an individual with MH goes under anesthetics and will not react. The reaction includes a dangerous rise in body temperature, metabolic and respiratory acidosis, hyperkalemia, and muscle rigidity. The response is due to an abnormal ryanodine receptor which is a Ca2+ release channel involved in excitation-contraction coupling. Normally, the