There are normal protein prions in the body, and these can turn abnormal and cause the illness. The body does not even recognize that the abnormal proteins are there, so it cannot fight off the disease. When the prion becomes abnormal, it changes its shape and can influence other proteins to change shape as well. This conversion takes place in lysosomes and causes the lysosome to rupture. When it ruptures, it leaks enzymatic contents into the cell. This causes the cell to digest itself and die, and the prions can then attack other cells. Once enough cells are killed, it can leave the visible holes in the brain. (Bassert, 2008) (U.S. Food and Drug Administration,
There are normal protein prions in the body, and these can turn abnormal and cause the illness. The body does not even recognize that the abnormal proteins are there, so it cannot fight off the disease. When the prion becomes abnormal, it changes its shape and can influence other proteins to change shape as well. This conversion takes place in lysosomes and causes the lysosome to rupture. When it ruptures, it leaks enzymatic contents into the cell. This causes the cell to digest itself and die, and the prions can then attack other cells. Once enough cells are killed, it can leave the visible holes in the brain. (Bassert, 2008) (U.S. Food and Drug Administration,