The macrolide are a group of compounds which comparable in the structure, the vast majority of which are gotten from numerous types of Streptomyces soil-borne bacteria (Scott et al., 1996). Macrolides are effective against Gram-positive bacteria, such as Streptococcus spp. what's more, Staphylococcus spp., Mycoplasma spp, however are marginally successful against Gram-negative living beings (Botsolou and Fletouris, 2001). Tilmicosin is a bacteriostatic macrolide antibiotic got from tylosin for veterinary use only. It is predominantly viable against Mycoplasma spp., Pasteurella spp., and many Gram-positive bacteria with viability against anaerobic bacteria and some Gram-negative respiratory bacteria such as Pasteurella multocida and Mannheimia
