Kidney Stone Disease Research Papers

Today, increasing prevalence of kidney stones is a global phenomenon due to change in living conditions and lifestyle. The urinary stone disease is a common multifactorial disorder estimated to occur in approximately 12% of the world population with a recurrence rate of 70-80% in male, and 47-60% in female (Araujo V., et al., 1999). Kidney stone disease is the third most common afflictions in urinary tract found in humans (Selvam et.al. 2001). Primary kidney stone formation and its recurrence is one of the biggest challenges faced by urologists today and remain a major source of morbidity in humans (Curhan et al., 1994). This disease occurs both in men and women but the risk is generally high in men and is becoming more common in young women (Selvam, 2002).
Urolithiasis is the deposition or formation of urinary calculi (Kidney stones, calculi, uroliths) in any part of the urinary system i.e the kidney, the ureters or the urinary bladder. Urinary calculi are an aggregation of solute materials from urine such as calcium, oxalate, phosphate and uric acid which forms stone (Singh SK., 2011). The size and nature of urinary calculi governs overall clinical manifestations of this complaint whereas urinary chemistry is one of the important factors …show more content…
et al., 2010).
Technological advancements have made great improvement in the removal/treatment of urinary stones, still some of the drawbacks of these methods exists which includes their being too costly for a common man and recurrence of stone formation along with a number of adverse side effects (Prasad K., 2007). Therefore, search for new antiurolithiatic drugs from natural sources has assumed greater importance as herbal drugs are cost effective and cause minimum side