Kaposi Sarcoma
Kaposi sarcoma (KS) is a tumor of endothelial cell origin commonly found in the Mediterranean, Jewish, Arabic and African populations. In patients on immunosuppression, human herpesvirus 8 (HHV-8) infection is reactivated in endothelial cells and conversion to spindle cells occurs.PMID: 16904612, PMID:17456614, PMID 15021843 The incidence of KS is markedly increased in patients with SOTRs (between 84 and 500 times more common) compared with the immune-competent population.PMID:10025742, PMID:159624, PMID:11750556 Mean time to development of KS after transplant is about 13 months, but a case has been reported even after 18 years. KS presents as lesions on the skin and mucosa. Lower extremity lesions are common, as in classic KS. Visceral involvement is reported in 25 to 30 percent of renal transplant recipients and 50 percent in heart or liver …show more content…
PMID:11158097, PMID: 12100502 However, HHV-8 can also be transmitted from the organ donor.PMID:11158097, PMID:12100502, PMID:9801396 Patients at high risk for developing KS can be identified by testing for HHV-8 antibody prior to transplantation. In high seroprevalence areas, organ donors can be screened for HHV-8 antibody, as HHV-8 can be transmitted from the donor to the recipient. PMID 12100502, PMID 9801396 Regamey et al reported an increase in HHV-8 seroprevalence from a baseline of 6.4 percent to 17.7 percent one year after renal transplantation. In the case of 6 patients who seroconverted, donor samples were positive for HHV-8 in five patients (83%). Eight seronegative patients, who received transplant from seronegative donors, did not seroconvert at one year follow up. PMID
Kaposi sarcoma (KS) is a tumor of endothelial cell origin commonly found in the Mediterranean, Jewish, Arabic and African populations. In patients on immunosuppression, human herpesvirus 8 (HHV-8) infection is reactivated in endothelial cells and conversion to spindle cells occurs.PMID: 16904612, PMID:17456614, PMID 15021843 The incidence of KS is markedly increased in patients with SOTRs (between 84 and 500 times more common) compared with the immune-competent population.PMID:10025742, PMID:159624, PMID:11750556 Mean time to development of KS after transplant is about 13 months, but a case has been reported even after 18 years. KS presents as lesions on the skin and mucosa. Lower extremity lesions are common, as in classic KS. Visceral involvement is reported in 25 to 30 percent of renal transplant recipients and 50 percent in heart or liver …show more content…
PMID:11158097, PMID: 12100502 However, HHV-8 can also be transmitted from the organ donor.PMID:11158097, PMID:12100502, PMID:9801396 Patients at high risk for developing KS can be identified by testing for HHV-8 antibody prior to transplantation. In high seroprevalence areas, organ donors can be screened for HHV-8 antibody, as HHV-8 can be transmitted from the donor to the recipient. PMID 12100502, PMID 9801396 Regamey et al reported an increase in HHV-8 seroprevalence from a baseline of 6.4 percent to 17.7 percent one year after renal transplantation. In the case of 6 patients who seroconverted, donor samples were positive for HHV-8 in five patients (83%). Eight seronegative patients, who received transplant from seronegative donors, did not seroconvert at one year follow up. PMID