Integumentary System: Anatomy and Physiology of the Skin The skin covers the entire body surface, making up most of a humans body weight. Skin tissue provides the human body with protection from mechanical, chemical, thermal damage, and bacteria. Along with this, the skin provides insulation while regulating heat and cushioning for tissues and organs. This body system also helps with the prevention of water loss, but also allows excretion of things such as urea, salts, and water. The skin has three layers the epidermis, dermis, and the hypodermis. The epidermis, which is made of epithelium, is the first layer of the skins and is made of five layers: the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and the stratum
