Drug is a substance that is used for diagnosis, cure, treatment, mitigation or prevention of disease. It is either a natural product, pharmaceutical preparation or chemical substance. Anti-inflammatory drugs are used for treating inflammation which is characterized by four cardinal signs: redness, pain, swelling and warmth. Most of anti-inflammatory drugs work by inhibiting prostaglandins secretion. Prostaglandins are the chemicals that responsible for promoting inflammation, fever and pain. They are produced by cyclooxygenase (COX) enzyme which are C0X-1 and COX-2 enzymes. Both COX-1 and COX-2 enzymes produce prostaglandin. However, only the prostaglandin synthesized by COX-1 enzyme can prevent the damaging effect of acid on intestinal and
