Bioinformatics coursework- report on IL2RG
IL2RG (Interleukin 2 receptor, gamma) serves as a receptor for cytokines IL2, IL4, IL7, IL15 and IL21 (Brandt et al, 2007). The binding of IL2 regulates the activation, differentiation and proliferation of lymphatic cells through both positive and negative feedback loops. It prevents autoimmune diseases during the maturation of T cells, as well as playing a key role in cell-mediated immunity (Liao et al, 2011).
The IL2RG gene is located on the chromosome X: 71,107,404-71,112,108 and the chromosome band is q13.1. The structure of the IL2RG-004 transcript contains 8 coding exons and 369 residues when translated (Flicek et al, 2014).The sequence of the translated protein is shown below:
>ENST00000374202 peptide: ENSP00000363318 …show more content…
They both share the fibronectin type III domain (FN3 domain). The folding of this specific 90 of amino acids allows the binding of protein to protein with adhesive characteristic (Bazan, 1990). The relationship between IL2RG and proteins such as ROBO2 (Roundabout homolog 2) is still unclear due to a lack of data as reflected in the low bootstrap value below 40.
The common gamma chain is essential for the function of the IL2R. Two of the functional significant patches on the gamma chain as highlighted in Figure 2. They are both important in binding to the interleukin receptors mentioned earlier (Olosz & Malek, 2002). Evidence from mutagenesis studies suggests that the patches provide the central degenerate recognition surfaces which allow the binding to all cytokines in the gamma chain dependent family. The polar interactions on the surface also aid the binding through the specific modulation that targets individual cytokine (Wang et al,
IL2RG (Interleukin 2 receptor, gamma) serves as a receptor for cytokines IL2, IL4, IL7, IL15 and IL21 (Brandt et al, 2007). The binding of IL2 regulates the activation, differentiation and proliferation of lymphatic cells through both positive and negative feedback loops. It prevents autoimmune diseases during the maturation of T cells, as well as playing a key role in cell-mediated immunity (Liao et al, 2011).
The IL2RG gene is located on the chromosome X: 71,107,404-71,112,108 and the chromosome band is q13.1. The structure of the IL2RG-004 transcript contains 8 coding exons and 369 residues when translated (Flicek et al, 2014).The sequence of the translated protein is shown below:
>ENST00000374202 peptide: ENSP00000363318 …show more content…
They both share the fibronectin type III domain (FN3 domain). The folding of this specific 90 of amino acids allows the binding of protein to protein with adhesive characteristic (Bazan, 1990). The relationship between IL2RG and proteins such as ROBO2 (Roundabout homolog 2) is still unclear due to a lack of data as reflected in the low bootstrap value below 40.
The common gamma chain is essential for the function of the IL2R. Two of the functional significant patches on the gamma chain as highlighted in Figure 2. They are both important in binding to the interleukin receptors mentioned earlier (Olosz & Malek, 2002). Evidence from mutagenesis studies suggests that the patches provide the central degenerate recognition surfaces which allow the binding to all cytokines in the gamma chain dependent family. The polar interactions on the surface also aid the binding through the specific modulation that targets individual cytokine (Wang et al,