Huntington's Disease Genetic Analysis

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Statistics:

Myers, R. H. (2004). Huntington’s Disease Genetics. NeuroRx, 1(2), 255–262 - This graph represents the onset age of Huntington’s disease. It ranges anywhere from 3 to 85. The average age of onset HD is between 30 and 55 years.

Hogarth P. 2013. “Huntington Disease” . American Academy of Neurology. [Internet]. [2013 May 27, cited 2015 Oct 16] Neurology 2013;80;e241-e243. Available from: http://www.neurology.org/content/80/22/e241.full.pdf

This graph represents the amount of CAG repeats representing the risk of onset Huntington’s Disease. 40 or more CAGs represents people that will eventually develop HD and their children have potential to inherit the gene, whereas 36-39 CAG repeats represents those that may or may not develop HD and
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-Impaired posture, balance and gait
-Slow or abnormal eye movements
-rigidity or muscle contractions
- Difficulty with the physical production of speech and swallowing. Cognitive Disorders have the following symptoms:
-Difficulty organizing, prioritizing or focusing on tasks
-difficulty in processing thoughts or “finding” words
-Hard time learning new information
-Lack of impulse control that can result in outbursts, acting without thinking and sexual promiscuity
-Lack of awareness of one’s own behaviors and abilities
-Lack of flexibility and a tendency to get stuck on one thought, idea, behavior or action. Psychiatric Disorders have the following symptoms:
Depressions is one of the most common psychiatric disorders that is associated with this disease.
-Feelings of irritability, sadness or apathy
-withdrawal socially
-insomnia
-fatigue or loss of energy
-frequent thoughts of death, dying, or suicide Some other psychiatric disorders associated with Huntington’s disease are:
-Obsessive-compulsive disorder
-Mania
-Bipolar disorder

Symptoms of Juvenile Huntington’s

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