“Sofosbuvir, which is also known as Sovaldi, is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase which …show more content…
Once the groups which already existed on the Phosphate atom have been separated, the two enzymes in the human body, Nucleotidyl and nucleoside diphosphate kinases, will add phosphatic groups to the molecule. The molecule becomes effective for the treatment of Hepatitis C virus only when Sofosbuvir as a prodrug is converted to Sofosbuvir as a drug. The drug needs to enter the Hepatitis C virus by disrupting the replication of the virus so that the drug can be an effective drug. Sofosbuvir needs to have three phosphate groups to be effective. Usually the first phosphate is harder to be added but the two others are added readily to Sofosbuvir and make the prodrug an active drug. The groups that are bonded to the phosphate group in the molecule by protecting the negative electric charge of the phosphate group and this will be done by facilitating the entry of Sofosbuvir into the Hepatitis C virus. When a phosphate groups is added to the drug makes Sofosbuvir more potent and also increase its ability to prevent the spread of Hepatitis C virus. This is also because of the NTP (nucleoside 5’-triphosphate) metabolite which is an agent that acts on the viral polymerase which leads to the termination of a chain and stops the viral