Haemolytic Anaemia Research Paper

Great Essays
Drug-induced immune haemolytic anaemia (DIIHA) is considered as a singular blood disorder as it only happens in one in every 1 million people. It is the condition when the body’s immune system is attacked by its own RBC when certain drugs like penicillin, cephalosporin antibiotics, methyldopa and a list of others are being taken. When RBCs are being broken down, it promotes anaemia in which oxygen is depleted in tissues. [8] To be able to understand, drug-induced oxidative haemolytic anaemia is a common heredity genetic disorder that is X-linked recessive in nature. In order words, the chances men will suffer from this diseases are more often than women as women will only be affected if they are homozygous. [4, 6, 7] Although both are rare blood …show more content…
Rao K.V. Drug-Induced Hematologic Disorders. [Internet]. New York: McGraw-Hill. 2014 Chapter 24. [Citied 2015 May 02] Available from: http://accesspharmacy.mhmedical.com/content.aspx?bookid=689&Sectionid=48811451
2. Yi C.B, Zieve D, Black B, Slon S, Wang N. Drug-induced immune haemolytic anemia. [Internet]. 2013. [Updated 2013 Mac 3, cited 2015 Mac 30]. Available from: http://www.nlm.nih.gov/medlineplus/ency/article/000578.htm
3. Gersten T, Zieve D, Black B, Slon S, Wang N, Ogilvie I. Glucose-6-phospgate dehydrogenase deficiency. [Internet]. 2014. [Updated 2014 Feb 24, cited 2015 April 15]. Available from: http://www.nlm.nih.gov/medlineplus/ency/article/000528.htm
4. UIC College of Pharmacy Drug Information Centre. What id G6PD deficiency? [Internet]. [Cited 2015 April 29]. Available from: https://www.uic.edu/pharmacy/services/di/G6PD.htm
5. Steven D. M. Jaundice in Adults: Get the Facts on Signs and Symptoms [Internet]. 2015 [Cited 2015 April 29]. Available from: http://www.medicinenet.com/jaundice_in_adults/article.htm
6. Spence E. G6PD Deficiency. [Internet]. 2009 September 7. [Updated 2014 April 15, Citied 2015 May 2]. Available from:

Related Documents

  • Great Essays

    OBJECTIVE #1 - The clinical manifestation of, and risk factors for, rhabdomyolysis • Rhabdomyolysis is a condition of skeletal muscle breakdown due to the release of intracellular components into the bloodstream, including myoglobin, creatine kinase, aldolase, lactate dehydrogenase, and electrolytes (DynaMed Plus, 2016). • The patient may experience systemic symptoms that may include fever, malaise, nausea, dyspepsia, emesis, muscle pain, weakness and swelling of injured muscles, tea-colored urine (DynaMed Plus, 2016). • High statin dosage and renal disease combined are associated with an increased risk for developing rhabdomyolysis (Wiley, 2006, p. 357). Other high risk factors include the use of drugs and/or alcohol, high body temperature,…

    • 1074 Words
    • 5 Pages
    Great Essays
  • Improved Essays

    APA Summary Paper

    • 412 Words
    • 2 Pages

    Past Medical & Surgical History, Pathophysiology of medical diagnoses (with APA citations) 1. Iron Deficiency Anemia: The most commonly occuring cause of anemia. Iron deficiency results in the lack of iron for hemoglobin synthesis within the body. This may be a result of low intake, diminished absorption, physiological increase in requirements, excessive iron loss, chronic renal failure, hemodyalisis, and idiopathic iron loss.…

    • 412 Words
    • 2 Pages
    Improved Essays
  • Great Essays

    Prophylactic hemin is a porphyrin chelate of iron, derived from red blood cells. Panhematin® is one of many prescribed medications for the treatment of acute intermittent porphyria attacks. Hemin is administered to avoid the progression of generalized pain to a neurological crisis. Because delta-aminolevulinic acid, the first step in heme synthesis, is regulated by a heme feedback mechanism, it was determined that acute porphyrias represent a deficiency in hepatocytes (Bissell & Wang, 2015). Hemin helps reduce 5’-aminolevulinate synthase-1 activity allowing the liver to reduce production of delta-aminolevulinic acid and porphobilinogen (Besur, Hou, Schmeltzer, & Bonkovsky,. 2014).…

    • 1580 Words
    • 7 Pages
    Great Essays
  • Improved Essays

    The evidence suggests this is assays for liver glucose-6-phosphatase activity showed a 20-fold lower activity per mg liver protein compared to control using either glucose-6-phosphate or glucose-1-phosphate as a substrate. 4. Why were glycogen levels elevated in liver but normal in skeletal muscle? What symptoms, if any, would appear for this patient under exercise?…

    • 475 Words
    • 2 Pages
    Improved Essays
  • Great Essays

    Introduction Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute life-threatening skin diseases characterized by extensive epidermal sloughing at the dermoepidermal junction resulting from keratinocyte apoptosis. 1 Both TEN and SJS are rare, affecting approximately 1 or 2 persons per 1, 000,000 populations annually, and are considered medical emergencies, as they are potentially fatal. 2 The exact molecular pathogenesis of TEN and SJS are not fully understood. TEN patients appear to, have an increased incidence of the haplotype HLA-B12, demonstrating an inability to detoxify intermediate reactive drug metabolites.…

    • 1362 Words
    • 6 Pages
    Great Essays
  • Brilliant Essays

    (2009). Drug-induced immune hemolytic anemia. ASH Education Book, 1, 73-79. doi: 10.1182/asheducation-2009.1.73 Garrison, C. (2009). Iron disorders institute guide to anemia.…

    • 246 Words
    • 1 Pages
    Brilliant Essays
  • Improved Essays

    In order for the body to function effectively, the body muscles and tissue need oxygen. If there is too little iron in the blood, it can causes a decrease in the amount of red cells in the blood that delivers oxygen to the body. Anemia is a common diagnostic term describing a decrease in number in function of erythrocytes or red blood cells (RBCs), and is the most widespread hematological disorder. In order to determine types of anemia, the anemia has to be classified by preforming a complete blood count along with other test. These test help provide a diagnosis that directs treatment and prognosis (Gulanick & Myers, 2014).…

    • 612 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    Treating Shingles Essay

    • 640 Words
    • 3 Pages

    Treating Shingles with Acupuncture What is “Shingles” and how do we get it? Shingles is a painful condition characterized by a skin rash caused by the same virus that causes chickenpox - the varicella zoster. It is also known as Herpes Zoster.…

    • 640 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    Thiopurine Essay

    • 486 Words
    • 2 Pages

    Allergic reactions to AZA or 6-MP typically occur within two to four weeks of start of therapy, and include fever, skin rash, myalgias, abdominal pain, pancreatitis and toxic hepatitis, which usually resolve with discontinuation of therapy28 -31. Other adverse effects related to the use of thiopurines such as pancreatitis, hepatitis and even myelosuppression may be associated with the low serum level of the TPMT converting enzyme26,27. Nevertheless, treatment intolerance, whose main complaints are myalgia, nausea and symptoms similar to a common cold (flu-like symptoms) are actually due to another factor. Early intolerance to azathioprine is believed to be derived from imidazole derivatives produced by the cleavage of azathioprine in 6-MP32. This could also explain why AZA-intolerant patients could be tolerant to the 6-MP…

    • 486 Words
    • 2 Pages
    Improved Essays
  • Superior Essays

    Anemia In SCD Patients

    • 1330 Words
    • 6 Pages

    Anemia in SCD patients can be caused by problems with the spleen known as splenic sequestration crisis and aplastic crisis. In splenic sequestration crisis the red blood cells become stuck in the spleen making it enlarge rapidly. Because these cells are trapped, there are fewer cells to circulate through the blood, resulting in anemia. Aplastic crisis occurs when a common infection known as Parvovirus B19 is caught. Parvovirus is a common infection in childhood also known as fifths disease, a viral illness entailing a low-grade fever, cold-like symptoms, and a bright red rash on the face.…

    • 1330 Words
    • 6 Pages
    Superior Essays
  • Improved Essays

    Pernicious anemia is a form of anemia discovered in the mid-19th century, commonly credited to the UK physician Thomas Addison for work in 1849, despite the facts that he was neither the first to describe nor name it (Lichtman et al. 563). A clinician by the name of Biermer officially named the disease, and it has been researched in depth while treated in various ways since this time. This work examines various aspects of pernicious anemia, considering fundamental traits of the disorder, mechanisms, symptoms, treatment, and other clinical work. Overall it is evident that while significant progress has been made in understanding the disease, additional work and development is required to better understand and treat it.…

    • 631 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    Anemia is the disease I chose for this disease diary. 16.2 billion people are affected by anemia. 3 million cases each year this disease is very common. The signs and symptoms of this disease are fatigue, cold hands and feet, pale skin, numbness, cognitive problems, headaches, chest pain, dizziness, and shortness of breath.…

    • 467 Words
    • 2 Pages
    Improved Essays
  • Improved Essays

    Sickle Cell Anemia Speech

    • 658 Words
    • 3 Pages

    It (Hydroxyurea) can cause a severe decrease in the number of blood cells in your bone marrow. It may also lead to serious infections or bleeding. Another type of treatment is bone marrow transplant. This treatment is effective it is if followed through properly, but it also has severe complications also. We have discussed the causes, and the treatments of Sickle Cell anemia.…

    • 658 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    Sickle cell anemia is a genetic blood disorder that causes normal red blood cells to form into an irregular shape, called sickled-cells. The sickle cell gene causes the body to produce abnormal hemoglobin. After a while, the hemoglobin will then cluster together anywhere in the body causing the blockage of blood flow through the blood vessels. This blockage deprives the tissues and blood of oxygen which can lead to many difficulties and problems. SCD becomes life-threatening when the damaged red blood cells begin to breakdown, when the spleen does not work properly or at all, or when it is unable to prevent infections from coming in.…

    • 1506 Words
    • 7 Pages
    Improved Essays
  • Superior Essays

    Low levels of vitamins or iron as a result of poor diet or disease will cause some sorts of anemia. Doctors might raise anemia patient’s vitamin B-12, folic acid, vitamin C supplements to extend iron absorption, or can also make modification in the patients’ diet. Many types of anemia are often cured by diet changes. Meats are richer in iron than the other food, particularly red meat. Iron is also available as supplements.…

    • 1187 Words
    • 5 Pages
    • 4 Works Cited
    Superior Essays