Guillain-Barrier Case

We reviewed several studies, each of which had a slightly different patient population to accommodate a different research question. Generally, each study broke down the incidence of Guillain-Barré based on age, gender, and health status (including several factors including Guillain-Barré case status, antecedent events, medical history, etc.). This gave us a broad scope of what types of patients are at risk for developing Guillain-Barre after vaccination and what type of time frame within that scope.
A study, for example, broke down patient information based on which type of vaccination they received and within those categories, they further looked at Brighton criteria levels. In this study, there were two groups – those who received the monovalent …show more content…
The monovalent inactivated vaccine is administered concurrently with the national peak of flu season. Patients are at highest risk in the 42 days immediately following vaccination, although it is still a ten-fold lower risk than the 1976 vaccine and there was no temporal cluster. In countries such as the Netherlands, pandemic flu vaccines are given much earlier than peak flu season, and in these countries, Guillain-Barré syndrome is seen at much lower rates after vaccination; however in the United Kingdom, seasonal flu vaccines are the norm, coinciding with peak flu season, and higher rates of Guillain-Barré are seen. Patients who had previous respiratory tract infections or exposure to the influenza virus had higher rates of Guillain-Barré syndrome in both vaccinated and unvaccinated patients. Overall, the recent vaccines have proven much safer than the 1976 H1N1 vaccine, with no statistically significant incidence of Guillain-Barré