Goodpasture Syndrome

Goodpasture syndrome is classified as an autoimmune disease due to B and T-cell mediated responses that result in the patient’s body to development antibodies against its own normal tissue, specifically the basement membranes of the glomerulus (glomerular basement membranes) and of the lungs (alveolar basement membranes) More specifically, the antibodies are developed against the noncollagenous domain 1 of the alpha 3-chain of type IV collagen). The noncollagenous domain 1 alpha 3 chain of type IV collagen is specifically found in the basement membranes of the glomeruli and alveoli resulting in distinct kidney and lung pathology in patients with Goodpasture syndrome This specific type of collagen is also found, but less abundantly, on the basement membranes of the testis, inner ear, eye, and choroid plexus sometimes resulting in other distinct, though potentially less serious consequences of the disease, …show more content…
However, cases of identical twins and siblings with Goodpasture syndrome have been reported
Despite lack of information on inheritance, Goodpasture syndrome is highly linked to the with 80% of patients carrying HLA-DRB1*15 haplotype As a result, to mutation resulting in Goodpasture syndrome In the Caucasian population, 70 to 80 percent of patients have been found to have the DRB1-15 antigen In addition to genetic causes, Goodpasture syndrome has been linked to chemical substances, such as organic solvents (ex. Tetrachloride, xylene, ethyl ether) and cigarette smoke Cigarette smoke is believed to be linked to lung manifestations of Goodpasture