Glyburide Vs Metformin

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Pharmaceuticals such as antihyperglycemic medications may also be an option to keep blood sugar levels on track. Oral antidiabetic agent metformin and glyburide have shown efficacy with no evidence of harm to the foetus, although long-term safety remains a concern (28.) When comparing to two, metformin was a 2.1 times higher failure rate than glyburide.
Metformin works by decreasing the amount of glucose the liver makes, keeping blood sugar levels low and boosting insulin response. Although metformin does cross the placenta and enter the baby’s bloodstream, the amount is small. Studies have not found evidence to suggest that metformin harms the fetus. Metformin has been shown to be equivalent to insulin in effectiveness. One randomized
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The insulin helps cells absorb energy from food, keeping blood sugar levels in the target range. A unique characteristic of glyburide that allows its use in pregnancy is its minimal transport across the human placenta (30.) As added therapy, glyburide can help reduce the daily dosage for those that require large amounts of insulin. The recommended starting dose of glyburide is 5mg, with a maximum dose of 20mg/day. Glyburide should be taken preferably 60 minutes before a meal to coincide with the postprandial glucose rush. Since glyburide has an extended duration of action, it can also be taken at bedtime to helped lower fasting blood sugar levels in the …show more content…
If the baby does not meet the criteria, then no points will be given.
During fetal flexion the baby should show bending of a limb or joint within 30 minutes and 2 points will be given. If the baby does not meet the criteria, no points will be given.
During fetal breathing the baby should display at least one episode of rhythmic breathing for 30 seconds or more within 30 minutes, then 2 points are given. If the breathing criteria isn’t met, then no points will be given.
The amniotic fluid, fluid that surrounds the baby, should be at least 2 cm in one or more adequate pockets around the baby. If there is adequate fluid around the baby, 2 points will be given, if not then no points will be given. Along with these test the patient should be keeping a log of their blood sugars to be reviewed by the physician. Blood sugar logs should be monitored every two weeks to ensure that the patients blood sugar levels are within normal range, if not an adjustment may need to be

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