Gastric carcinoid tumors originate from enterochromaffin-like (ECL) cells. ECL cells are confined in the gastric fundus and corpus cells (L. Vannella et al., 2011). ECL cells have the task of secreting histamine, which leads the secretion of parietal cells (L. Vannella et al., 2011). Histamines are produced by the immune system, and in response causes inflammation. Parietal cells are the epithelial cells that secrete hydrochloric acid (HCL) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and in the body of the stomach.
Gastric carcinoids are classified into three different subgroups: Type I, Type II, and Type III (L. Vannella et al., 2011). Type I gastric carcinoids cause atrophic body …show more content…
Vannella et al., 2011). Type I gastric carcinoids are 75% of all gastric carcinoids and occur in 1-2% of ABG patients (Delle Fave G. et al., 2012). Type I Gastric Carcinoids, are generally present in 77% of cases as multifocal polypoid mucosal protrusions (<10 mm) in the corpus and/or fundus of the stomach (G. Cadiot et al., 2010). 27% are limited to the mucosa, 64% only invading to the mucosa and/or submucosa and only 9% invading the muscularis propria (G. Cadiot et al., 2010). Type I gastric carcinoids are usually not invasive. The person usually has multiple carcinoids if type I is present, and they usually are well differentiated. Type I gastric carcinoids are asymptomatic. They are usually discovered during a routine upper gastrointestinal endoscopy for other …show more content…
Type I Gastric Carcinoids, 9 out of 367 (2.4%) patients [six women, median age 59 (range 40-72) years] were diagnosed with type I gastric carcinoids at the initial diagnosis of CAG (L. Vannella et al., 2011). The chart shows that all patients besides one had polys of the body with a diameter between 0.3 and 3 cm at gastroscopy (L. Vannella et al., 2011). In six out of nine (66.7%) patients with type I gastric carcinoids, the body gastric mucosa presented a severe atrophy, in the remaining cases the atrophy was moderate (L. Vannella et al., 2011). 40% of the patients had a recurrence rate.
Patients Gender Age (years) Gastrin (pg/mL) CgA (ng/mL) Body atrophy* Pernicious anaemia Endoscopic findings Detection of typeIGC Recurrence
1. * Scored accordingly to the Sydney System. 1 F 45 305 60 2 No Body polyp of 0.5 cm At diagnosis
Gastric carcinoids are classified into three different subgroups: Type I, Type II, and Type III (L. Vannella et al., 2011). Type I gastric carcinoids cause atrophic body …show more content…
Vannella et al., 2011). Type I gastric carcinoids are 75% of all gastric carcinoids and occur in 1-2% of ABG patients (Delle Fave G. et al., 2012). Type I Gastric Carcinoids, are generally present in 77% of cases as multifocal polypoid mucosal protrusions (<10 mm) in the corpus and/or fundus of the stomach (G. Cadiot et al., 2010). 27% are limited to the mucosa, 64% only invading to the mucosa and/or submucosa and only 9% invading the muscularis propria (G. Cadiot et al., 2010). Type I gastric carcinoids are usually not invasive. The person usually has multiple carcinoids if type I is present, and they usually are well differentiated. Type I gastric carcinoids are asymptomatic. They are usually discovered during a routine upper gastrointestinal endoscopy for other …show more content…
Type I Gastric Carcinoids, 9 out of 367 (2.4%) patients [six women, median age 59 (range 40-72) years] were diagnosed with type I gastric carcinoids at the initial diagnosis of CAG (L. Vannella et al., 2011). The chart shows that all patients besides one had polys of the body with a diameter between 0.3 and 3 cm at gastroscopy (L. Vannella et al., 2011). In six out of nine (66.7%) patients with type I gastric carcinoids, the body gastric mucosa presented a severe atrophy, in the remaining cases the atrophy was moderate (L. Vannella et al., 2011). 40% of the patients had a recurrence rate.
Patients Gender Age (years) Gastrin (pg/mL) CgA (ng/mL) Body atrophy* Pernicious anaemia Endoscopic findings Detection of typeIGC Recurrence
1. * Scored accordingly to the Sydney System. 1 F 45 305 60 2 No Body polyp of 0.5 cm At diagnosis