Misdiagnosis made, is cancer, soft tissue sarcoma, aggressive juvenile fibromatosis, fibrous dysplasia, progressive osseous heteroplasia, myositis ossificans traumatica, ankylosing spondylitis and lymphedema.
Misdiagnosis can be avoided by simply examine the patient’s great toes as a first sign of FOP.
(e) Relation to cancer and soft tissue sarcoma
FOP can be misdiagnosed as cancer because tumor-like lumps are associated …show more content…
(g) Relation to fibrous dysplasia
Fibrous dysplasia is a disorder where normal bone are replaced whth scar-like (fibrous) tissue. This bone are weakened and it can deformed or fractured. Mostly only one bone is affected — most commonly the skull or a long bone in the arms or legs. FOP patients are normally not misdiagnosed with fibrous dysplasia. Areas commonly affected by fibrous dysplasia are not affected in FOP.
(h) Relation to progressive osseous heteroplasia (POH)
Progressive osseous heteroplasia (POH) is a disease where bones form within skin and muscle tissue. In FOP bones form outside the skeleton –heteroptic ossification. Symptoms of POH are dermal ossification, no congenital malformations, no tumor-like swellings, the asymmetric mosaic distribution of lesions, the absence of predictable regional patterns of heterotopic ossification, and the predominance of intramembranous rather than endochondral ossification.