Etomidate, which is an imidazole derivative and an ester, is the most commonly used anesthetic induction agent and characterized by rapid onset, with minimal side effects on cardiovascular and respiratory functions, as well as minimum histamine release. These properties make it especially useful for cardiac-compromised patients. [7] However, it can suppress adrenal function through blockade of 11β-hydroxylase. This suppression persists for at least 24 hours, and some authors suggest that it may last up to 72 hours. This could harm patients with critical illness such as severe sepsis or septic shock. [8]Since it’s introduction in the 1970s, Propofol has become the most widely used IV hypnotic Today. The most prominent effect of Propofol is a
