Why is the use of a placebo in medical research controversial?
Controversy exists regarding using placebo in medical research can control groups in clinical trials when effective treatments exist. The controversy has centered on several issues. The first involves the methodological superiority of placebo-controlled trials of discerning treatment effects. Secondly, it is unclear whether the treatment effects encompass absolute treatment effects, including placebo effects or are confined to treatment-specific effects excluding placebo effects. Thirdly, there are concerns that subjects in the placebo group could be exposed to a high risk for developing serious adverse events.
What is the difference between clinical practice and medical research?
Clinical practice must be conducted according to the written protocol with a full understanding of the risk to the subjects. The laws, regulations and guidelines for clinical practice are detailed and very specific. Medical research is an experiment that involves a test article and one or more human subjects. When you receive medical research from your own doctor, he or she develops a plan of care just for you. When you take part in a clinical practice study, you and the researcher must follow a …show more content…
This in turn reflects a number of important ethical principles, which should underpin all research involving human beings. In response to such violations of human dignity resulting from research on human beings in the United States, numerous sets of guidelines were established by different entities that incorporated and even expanded on the principles set forth in the Nuremberg code. This is a set of research ethics principles for human experimentation set as a result of the subsequent Nuremberg Trials at the end of the Second World
Controversy exists regarding using placebo in medical research can control groups in clinical trials when effective treatments exist. The controversy has centered on several issues. The first involves the methodological superiority of placebo-controlled trials of discerning treatment effects. Secondly, it is unclear whether the treatment effects encompass absolute treatment effects, including placebo effects or are confined to treatment-specific effects excluding placebo effects. Thirdly, there are concerns that subjects in the placebo group could be exposed to a high risk for developing serious adverse events.
What is the difference between clinical practice and medical research?
Clinical practice must be conducted according to the written protocol with a full understanding of the risk to the subjects. The laws, regulations and guidelines for clinical practice are detailed and very specific. Medical research is an experiment that involves a test article and one or more human subjects. When you receive medical research from your own doctor, he or she develops a plan of care just for you. When you take part in a clinical practice study, you and the researcher must follow a …show more content…
This in turn reflects a number of important ethical principles, which should underpin all research involving human beings. In response to such violations of human dignity resulting from research on human beings in the United States, numerous sets of guidelines were established by different entities that incorporated and even expanded on the principles set forth in the Nuremberg code. This is a set of research ethics principles for human experimentation set as a result of the subsequent Nuremberg Trials at the end of the Second World