This article presented an experimental level three study. The reason for this study was to evaluate the harms and benefits or harms associated with pantoprazole. The thought is that pantoprazole increases the risk of VAP, CDI, and GI bleeding in critically ill patients who are mechanically ventilated. Rates of VAP, CDI, and GI bleeding represented the dependent variable and pantoprazole and placebo represent the independent variable in this study. The two types of data collected were nominal and ratio. Researchers included ICU patients who were mechanically ventilated for more than 24 hours and who would be receiving enteral nutrition within 48 hours of admission. The study concludes that there is no significant evidence which proves giving
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The participants included those admitted to the ICU who were expected to be mechanically ventilated for more than 24 hours and who would also be receiving enteral nutrition within 48 hours of admission. Of the 1,632 patients admitted to ICUs at an academic medical center, 209 were eligible to participate. Data were collected by chart review. The nominal data collected were gender, medical history, medications, source of ICU admission, and ICU diagnostic group. The ratio data included age and number of HAIs. Participants were randomly assigned to receive either 40mg of pantoprazole in 10mL of normal saline IV or placebo which was 10mL of normal saline IV. This resulted in 104 participants receiving the pantoprazole and 105 participants receiving the placebo. Treatment was initiated immediately after beginning mechanical ventilation. This protocol was continued for once a day until either the patient was no longer mechanically ventilated or for a total of 14 days. This study was approved by the Research Ethics Committee of the Royal Adelaide Hospital. Delayed opt-out consent was obtained from the patient’s surrogate decision maker or the patient. Descriptive and inferential statistical analysis were conducted. The inferential tests included t-test and Wilcoxon signed rank test. The level of statistical significance was p <
The participants included those admitted to the ICU who were expected to be mechanically ventilated for more than 24 hours and who would also be receiving enteral nutrition within 48 hours of admission. Of the 1,632 patients admitted to ICUs at an academic medical center, 209 were eligible to participate. Data were collected by chart review. The nominal data collected were gender, medical history, medications, source of ICU admission, and ICU diagnostic group. The ratio data included age and number of HAIs. Participants were randomly assigned to receive either 40mg of pantoprazole in 10mL of normal saline IV or placebo which was 10mL of normal saline IV. This resulted in 104 participants receiving the pantoprazole and 105 participants receiving the placebo. Treatment was initiated immediately after beginning mechanical ventilation. This protocol was continued for once a day until either the patient was no longer mechanically ventilated or for a total of 14 days. This study was approved by the Research Ethics Committee of the Royal Adelaide Hospital. Delayed opt-out consent was obtained from the patient’s surrogate decision maker or the patient. Descriptive and inferential statistical analysis were conducted. The inferential tests included t-test and Wilcoxon signed rank test. The level of statistical significance was p <