• Home Page
  • Eliquis Vs. Warfarin: A Case Study

Eliquis Vs. Warfarin: A Case Study

Superior Essays
Show More
Eliquis vs. Warfarin
Jennifer Lockie
Joliet Junior College

According to the American Heart Association, there are, at minimum, 2.7 million Americans currently diagnosed with atrial fibrillation (a-fib). This condition accounts for 15-20% of strokes. As a result, patients are prescribed an anticoagulation therapy to decrease this risk (What is atrial fibrillation, 2016). While warfarin has been the medication of choice for decades, new anticoagulation medications have been approved in recent years that may be more effective with less risk. One of the more recent medications approved is Eliquis (apixaban) (Cassavaugh & Stummer, 2014). Is Eliquis more beneficial for patients with nonvalvular a-fib compared to warfarin? Warfarin …show more content…
The INR is a specific mathematical calculation of the PT or prothrombin time. This test is used to monitor the efficacy of anticoagulation therapy. The therapeutic range for patients taking warfarin is an INR of 2.0 to 3.0 (Malarkey & McMorrow, 2012, p.526). If the patient’s INR is too low, then the medication is not reaching its therapeutic goal. If the INR results are too high, then the patient will be at an increased risk of bleeding. Factors that can modify the effectiveness of warfarin and increase/decrease the PT/INR include medications, alcohol, and foods containing vitamin K (A Patient's Guide to Taking Warfarin, 2014). If patients taking Eliquis experience increased bleeding or need surgery, the doctor may order a PT/INR or anti-factor Xa tests to gauge the patient’s coagulation factors (Guidelines for the Management of Anticoagulant, …show more content…
(n.d.). Retrieved October 18, 2016, from http://reference.medscape.com/drug/lovenox-enoxaparin-342174

Guidelines for the Management of Anticoagulant and Anti-Platelet Agent Associated Bleeding Complications in Adults. (n.d.). Retrieved October 18, 2016, from http://wsp.mclaren.org/Lapeer/files/Guidelines for the Management of Anticoagulant Agents.pdf

Kreuziger, L. M., Keenan, J. C., Morton, C. T., & Dries, D. J. (2014, July 20). Management of the Bleeding Patient Receiving New Oral Anticoagulants: A Role for Prothrombin Complex Concentrates. Retrieved October 18, 2016, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127295/

Malarkey, L. M., & McMorrow, M. E. (2012). Saunders Nursing Guide to Laboratory and Diagnostic Tests (2nd ed.), p.526. St. Louis, MO: Elsevier/Saunders.

VHA Pharmacy Benefits Management Services, Medical Advisory Panel, and VISN Pharmacist Executives. Drug Class Review: Target Specific Oral Anticoagulants Dabigatran (Pradaxa), Rivaroxaban (Xarelto), and Apixaban (Eliquis). (2013, September). Retrieved October 18, 2016, from

Related Documents

  • Superior Essays

    Clb 479 Unit 5 Health And Social Care M1
    • 1036 Words
    • 5 Pages

    Clb 479 Unit 5 Health And Social Care M1

    Hassan Bedeiry Dr. Brenda Schoffstall CLB 479-M1 20 October 2015 This case study talks about a male trauma patient aged 36 years who was transported to a health care facility for emergency surgery. A sample was taken to the blood bank for pre-transfusion testing; including type and antibody screen and crossmatch for six units of PRBCs. After the units were issued to the OR, the patient received five compatible units of RBCs. After the infusion of about 100mL of the sixth unit, the transfusion stopped because the patient became hypotensive.…

    • 1036 Words
    • 5 Pages
    Superior Essays
    Read More
  • Improved Essays

    Nr340 Week 3 Assignment For Research Paper
    • 1272 Words
    • 6 Pages

    Nr340 Week 3 Assignment For Research Paper

    Arrhythmias may occur; treatment should be immediately available. Infusion site (and any other potential bleeding sites) should be monitored and patient assessed for hemorrhage during therapy and for 1 hour following therapy. Strict bedrest should be maintained and bleeding precautions should be instituted. Rationale for medication: Treatment of acute ischemic stroke Trade name: Acetylsalicylic acid…

    • 1272 Words
    • 6 Pages
    Improved Essays
    Read More
  • Improved Essays

    Ap Case Study Eliot
    • 946 Words
    • 4 Pages

    Ap Case Study Eliot

    Reducing the effect of warfarin will lower the INR and stop the bleeding episodes. Henceforth, cimetidine to be discontinue from Eliot’s medication list and an alternative antacid such as Pepcid will be considered at this time (Anticoagulation EUROPE (UK), 2015). Digoxin- Pseudoephedrine interaction: Using digoxin together with pseudoephedrine can cause an irregular heart rhythm. Pseudoephedrine is a sympathomimetic agent, which can activate β-receptors of the heart leading to increases in heart rate and α-receptors in vascular smooth muscle leading to vasoconstriction and increases in blood pressure (Sager et al., 2013).…

    • 946 Words
    • 4 Pages
    Improved Essays
    Read More
  • Improved Essays

    The Pros And Cons Of Anticoagulants
    • 262 Words
    • 2 Pages

    The Pros And Cons Of Anticoagulants

    Anticoagulants are blood thinning medications that are used for the treatment and prevention of blood clots. They act mainly by slowing blood clot formation and thus preventing associated complications1.Their approved Food and Drug Administration (FDA) indications include prophylaxis and treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) and preventing complications associated with atrial fibrillation such as stroke2. For the past years, vitamin-k antagonist (warfarin) has been the primary treatment for a wide range of coagulation related indications3. However, limitations of warfarin have led to the discovery of a new generation of anticoagulants.…

    • 262 Words
    • 2 Pages
    Improved Essays
    Read More
  • Great Essays

    Evolocumab Research Paper
    • 1540 Words
    • 7 Pages

    Evolocumab Research Paper

    Each group received an injection right under the skin every two weeks. One group received an injection with the active ingredients, and the placebo group received an injection without. The efficacy end point, which tests whether the hypothesis is true or not, was determined by cardiovascular events. These events include cardiovascular death, angina or chest pain, a myocardial infarction, or coronary revascularization. Coronary revascularization is a procedure in which they bypass an artery to restore blood flow to the heart.…

    • 1540 Words
    • 7 Pages
    Great Essays
    Read More
  • Improved Essays

    Dabigatran Case Study
    • 463 Words
    • 2 Pages

    Dabigatran Case Study

    A reduced dose of apixaban is recommended if two of three criteria are present: serum creatinine ≥ 1.5 mg/dl, age ≥ 80 years, body weight ≤ 60kg. The recommendation regarding a reduced dose of rivaroxaban (15mg) in CKD was based on a second analysis of the ROCKET-AF (15). Among patients with mild or moderate renal impairment rivaroxaban preserved the benefit of warfarin in preventing stroke and systemic embolism, while bleeding events were similar but fatal bleeding occurring less often with rivaroxaban (16). In respect to apixaban, a second analysis of the ARISTOTELE study (17), which included 3017 patients with CrCl of 25-50 mL/min showed a same efficacy of apixaban compared to warfarin in…

    • 463 Words
    • 2 Pages
    Improved Essays
    Read More
  • Improved Essays

    Rivaroxaban Research Paper
    • 554 Words
    • 3 Pages

    Rivaroxaban Research Paper

    Rivaroxaban Rivaroxaban is an anticoagulant medication commonly used in the prevention of cerebrovascular accidents and pulmonary embolism in patients suffering from atrial fibrillation. According to a study published in Thrombosis, a peer-reviewed medical journal, rivaroxaban proves to be just as effective at cerebrovascular accident and pulmonary embolism prevention as warfarin (Gómez-Outes et al., 2013). Rivaroxaban has also been approved for the prevention of venous thromboembolism and deep vein thrombosis in individuals who have undergone hip or knee replacement surgery. Rivaroxaban is available as an oral tablet and has a bioavailability of approximately 90%.…

    • 554 Words
    • 3 Pages
    Improved Essays
    Read More
  • Decent Essays

    Xarelto Case Essay
    • 474 Words
    • 2 Pages

    Xarelto Case Essay

    Since the mid-2015, 2000 cases have been involved in the Xarelto litigation and it is highly predicted that several thousand cases more will be filed over the next few years. Almost all of the complaints are against the drug manufacturers who failed to research properly on the bleeding risks associated with Xarelto while producing anticoagulants. The cases are primarily designed to help parties assess how juries may respond to certain evidence that is likely to be repeated throughout the litigation. When it comes to settling the negotiations, the drug manufacturers are always at stake since they have to face substantial liability if they fail to settle the claims. • Factors considered Settling of Xarelto cases depends on what the jury wishes…

    • 474 Words
    • 2 Pages
    Decent Essays
    Read More
  • Improved Essays

    Von Willebrand Disease Research Paper
    • 716 Words
    • 3 Pages

    Von Willebrand Disease Research Paper

    Always check with your health care provider before taking any medicine. You will need to avoid over-the-counter medicines that can affect the clotting process. Some of these are: Aspirin and other drugs that contain salicylates. Nonsteroidal anti-inflammatory drugs (NSAIDs). Exercise Exercise regularly and maintain a healthy weight.…

    • 716 Words
    • 3 Pages
    Improved Essays
    Read More
  • Improved Essays

    Onabotulinumtoxina Pilot Study
    • 784 Words
    • 4 Pages

    Onabotulinumtoxina Pilot Study

    Of the 12 that dropped out of the onabotulinumtoxinA group, three noted that adverse effects caused them to discontinue the study. All other individuals were either lost to follow up. Despite these limitations, this study was important for clinical practice because it allows clinicians to better understand the tolerability and efficacy of onabotulinumtoxinA in comparison to topiramate. If a patient has difficulty tolerating the effects of topiramate, this study allows clinicians to better educate their patients on a potentially more tolerable and similarly efficacious alternative.…

    • 784 Words
    • 4 Pages
    Improved Essays
    Read More
  • Improved Essays

    The Pros And Cons Of Coumadin
    • 1431 Words
    • 6 Pages

    The Pros And Cons Of Coumadin

    Since these new drugs haven’t been studied as much, the new drugs can cause an increased risk for bleeding in certain people. Coumadin has been studied for a long time and they have done many tests to make sure that it is completely safe. While there are many pros of taking Coumadin over other drugs there are also some cons. Since there are newer drugs that are similar to Coumadin they are also more advanced than Coumadin in some ways. The new drugs start working a lot faster than Coumadin does and the effects done last long after stopping taking them (Carter, 2017).…

    • 1431 Words
    • 6 Pages
    Improved Essays
    Read More
  • Improved Essays

    Movantik And Amitiza
    • 242 Words
    • 1 Pages

    Movantik And Amitiza

    Both drugs are category C in pregnant patients, due to lack of studies. In lactating patients, both drugs…

    • 242 Words
    • 1 Pages
    Improved Essays
    Read More
  • Improved Essays

    Pathophysiology Related To Thethrombus Vs. Embolus
    • 1404 Words
    • 6 Pages

    Pathophysiology Related To Thethrombus Vs. Embolus

    1. Discuss the pathophysiology related to CVA due to thrombus vs. embolus. Describe the stages in the development of an atheroma. There are a few different pathophysiologies that can lead to a stroke.…

    • 1404 Words
    • 6 Pages
    Improved Essays
    Read More
  • Improved Essays

    Vascular Surgery Patient Population
    • 869 Words
    • 4 Pages

    Vascular Surgery Patient Population

    Variable choice: Medications are an important part of patient care. It has been shown that as the number of medications, the frequency of taking medications or the complexity of the prescription increases the more difficulty patients have in complying with the therapy. Compliance with medications is extremely important as medication non-compliance; misuse and drug-drug interactions may cause admission and/or readmission to the hospital, increased length of hospital stay and may lead to serious complications, including organ failure or death. I have long been an advocate for having an accurate medication list at every clinic visit therefore I choose to look at the number of medications the vascular surgery patient population is taking.…

    • 869 Words
    • 4 Pages
    Improved Essays
    Read More
  • Improved Essays

    Case Study Of Cobas Taqscreen MPX Test
    • 826 Words
    • 4 Pages

    Case Study Of Cobas Taqscreen MPX Test

    General Principles of Software Validation; Final Guidance for Industry and FDA Staff. Clinical studies: Reproducibility: This study showed that the cobas MPX test shows highly reproducible results across sites, lots and days at different concentrations. Clinical specificity: Whole blood donor: A total of 13,306 whole blood donations were tested and the clinical specificity foe individual testing was found to be 99.895%. Similarly, in pool testing the results were found to 99.866% from 10,500 pools tested.…

    • 826 Words
    • 4 Pages
    Improved Essays
    Read More

Related Topics

Ready To Get Started?
Discover
Company
Follow
©2024 Cram.com
Privacy Policy |  About Ads |  Site Map |  Advertise  | 
  • Cookie Settings