g) Solubility: soluble in methanol, slightly soluble in water (13.4 mg/ml) and very slightly soluble in dichloromethane
h) Route of administration: Oral
i) Excretion: kidney
j) Therapeutic category: Antiretroviral drug
k) Metabolism: The cytochrome P450 enzyme system is not involved with the metabolism of Tenofovir disoproxil or Tenofovir.
l) pKa value: 3.75
m) Trade Name: Viread
2.2.5 Drug profile of Efavirenz:
Efavirenz is an antiretroviral drug and it belongs to the class of Non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used for the treatment of HIV type 1. Efavirenz was approved by the Food Drug and Administration on 21 September 1998. Efavirenz inhibits the activity of reverse transcriptase enzyme, which copies HIV …show more content…
It is used for the treatment of Human Immunodeficiency Virus (HIV) infection. Lamivudine was approved by the Food Drug and Administration on 17 November 1995. It is an analogue of cytidine. NRTIs block reverse transcriptase, an enzyme of HIV. Thus, blocking reverse transcription interrupts HIV replication and reduce the amount of HIV in the body. Lamivudine used in combination with other antiretroviral drugs. This was available in the name of Epivir. It is also used to treat Hepatitis B virus infection. The recommended dosage of Lamivudine is 300 mg taken once a day or 150 mg taken twice a …show more content…
It is used for the treatment of Human Immunodeficiency Virus (HIV) infection and also used to prevent transmission of HIV from mother to child during birth. Zidovudine was approved by the Food Drug and Administration on 20 March 1987. It is an analogue of thymidine. Zidovudine inhibits the activity of reverse transcriptase, an enzyme of HIV, which converts HIV RNA into viral DNA. NRTIs interrupts reverse transcription, hence it prevents HIV from multiplying and prevents HIV infecting human cells. This drug is always used in combination with other HIV medicines. Zidovudine is available in the name of Retrovir. The recommended dosage of Zidovudine is 600 mg every day in divided
h) Route of administration: Oral
i) Excretion: kidney
j) Therapeutic category: Antiretroviral drug
k) Metabolism: The cytochrome P450 enzyme system is not involved with the metabolism of Tenofovir disoproxil or Tenofovir.
l) pKa value: 3.75
m) Trade Name: Viread
2.2.5 Drug profile of Efavirenz:
Efavirenz is an antiretroviral drug and it belongs to the class of Non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used for the treatment of HIV type 1. Efavirenz was approved by the Food Drug and Administration on 21 September 1998. Efavirenz inhibits the activity of reverse transcriptase enzyme, which copies HIV …show more content…
It is used for the treatment of Human Immunodeficiency Virus (HIV) infection. Lamivudine was approved by the Food Drug and Administration on 17 November 1995. It is an analogue of cytidine. NRTIs block reverse transcriptase, an enzyme of HIV. Thus, blocking reverse transcription interrupts HIV replication and reduce the amount of HIV in the body. Lamivudine used in combination with other antiretroviral drugs. This was available in the name of Epivir. It is also used to treat Hepatitis B virus infection. The recommended dosage of Lamivudine is 300 mg taken once a day or 150 mg taken twice a …show more content…
It is used for the treatment of Human Immunodeficiency Virus (HIV) infection and also used to prevent transmission of HIV from mother to child during birth. Zidovudine was approved by the Food Drug and Administration on 20 March 1987. It is an analogue of thymidine. Zidovudine inhibits the activity of reverse transcriptase, an enzyme of HIV, which converts HIV RNA into viral DNA. NRTIs interrupts reverse transcription, hence it prevents HIV from multiplying and prevents HIV infecting human cells. This drug is always used in combination with other HIV medicines. Zidovudine is available in the name of Retrovir. The recommended dosage of Zidovudine is 600 mg every day in divided