Physiology of early miscarriage
Sporadic miscarriage occurs before embryo development represent a physiological phenomenon, which prevents congenitally malformed or chromosomally abnormal embryos to progress to viability. Congenital and/or chromosomal abnormalities incompatible with life observed in 85% of early clinical miscarriages.[5]
However, some aneuploidies can survive to term pregnancy as trisomy 21. The fetal chromosomal abnormalities of maternal origin are related to the advanced maternal age and caused during the first meiotic division. In addition; chromosomal aberrations are responsible for 29-60% of RM.[5] Recently; the fetal DNA containing cells isolated from the maternal plasma from the 7th gestational week for prenatal diagnosis
Sporadic miscarriage occurs before embryo development represent a physiological phenomenon, which prevents congenitally malformed or chromosomally abnormal embryos to progress to viability. Congenital and/or chromosomal abnormalities incompatible with life observed in 85% of early clinical miscarriages.[5]
However, some aneuploidies can survive to term pregnancy as trisomy 21. The fetal chromosomal abnormalities of maternal origin are related to the advanced maternal age and caused during the first meiotic division. In addition; chromosomal aberrations are responsible for 29-60% of RM.[5] Recently; the fetal DNA containing cells isolated from the maternal plasma from the 7th gestational week for prenatal diagnosis