The D2 dopamine receptor has an extremely important function in the nervous system. The D2 receptor is metabotropic: it is coupled with a G-Protein linked receptor. This implies that a dopamine receptor is in the G protein-coupled receptor class. They are prominent in the vertebrae of the central nervous system. The synthesis of a dopamine receptor is extremely complicated. The subtypes of receptors differ in function and structure during DNA synthesis by the absence or presence of introns during their respective coding sequences (Missale et al, 1998).
The D2 receptor can be put through the process of alternative splicing, which can synthesize two isoforms of the receptor: D2L (long) and D2S (short). It is found pre-synaptically as D2S, which is also known as an …show more content…
Dopamine receptors can be affected by agonists, partial agonists, and antagonists. An agonist is a drug that causes an action when it binds to the receptor. It essentially tricks the receptor into believing that it is a neurotransmitter and causes the receptor to produce the same action that a real neurotransmitter would. Some examples of agonists are bromocriptine, cabergoline, pramipexole, ropirinole, and apomorphine. An antagonist is a drug that is an inhibitor of neurotransmitter receptors. It binds to the receptors of the postsynaptic terminal and blocks the normal action of the transmitter. Metoclopramide and some antipsychotics are examples of antagonists. A partial agonist is a drug that binds to a receptor, but only has a partial effect on the receptor versus having a full agonist (Wikipedia, 2015). An example of a partial agonist drug is apripazole. There are not many options for the treatment of the D2 receptor besides medications. However, as technology and medicine progresses, there are always new medications and treatments being developed to help with the treatment of dopamine