People who are prone to delta F508 mutation tend to have more critical symptoms of cystic fibrosis because of the lack of chloride ion transport, needed to control the thin layer of mucus that can be removed by the cilia lining the lungs and organs. The lack of chloride ion transport causes a thick mucus layer that the cilia can not remove, which in result traps bacteria causing disease. The chloride channels are to let chloride out of the epithelium cells. Someone who does that have cystic fibrosis the channels will open a fair amount of times in order to keep it balanced inside and outside of the cells, On the other hand, those with CF the channels do not work properly and the chloride ions build up in the
People who are prone to delta F508 mutation tend to have more critical symptoms of cystic fibrosis because of the lack of chloride ion transport, needed to control the thin layer of mucus that can be removed by the cilia lining the lungs and organs. The lack of chloride ion transport causes a thick mucus layer that the cilia can not remove, which in result traps bacteria causing disease. The chloride channels are to let chloride out of the epithelium cells. Someone who does that have cystic fibrosis the channels will open a fair amount of times in order to keep it balanced inside and outside of the cells, On the other hand, those with CF the channels do not work properly and the chloride ions build up in the