The fraction at 51 °C /80 Pa from the remaining solution was collected under reduced pressure distillation. The final product EEGE monomer is a colorless liquid (Yield: 76 %). Synthesis…
The product was purified by preparative HPLC on a C18 column. The product was freeze dried and analyzed using LCMS, analytical HPLC, and NMR. 21 was obtained as a white solid with a yield of 44.4 mg (0.025 mmol, 61%). Pro8 Spacer (12) (38 mg, 0.037 mmol) and 16 (34.13 mg, 0.089 mmol) were dissolved in 810 µL DMF. Copper sulfate (1.5 mg, 0.006 mmol) and sodium-L- ascorbate (2.4 mg, 0.012 mmol) were dissolved in 90 µL H2O.…
Assignment #2: The Replication of DNA in Escherichia Coli Due Date: Feb 8, 2016 at 9:00 AM CST 1a. A procedure in which a small amount of DNA material is immersed in concentrated solution, cesium chloride (CsCl), and soon after placed in centrifuge until the point where equilibrium is achieved is called density-gradient centrifugation. Contrasting techniques involving diffusion and sedimentation form a persisting CsCl concentration gradient. Furthermore, the concentration gradient and pressure of centrifugal force results in increased density.…
The goal of the lab was to identify an unlabeled compound found in the chemistry stockroom to be able to dispose of it properly. This lab demonstrated the process of identifying an unknown compound as well as synthesizing the compound. Identifying the compound consisted of performing various tests to detect the chemical and physical properties of the compound and comparing it to the list of possible compounds. The tests conducted were the solubility test which the compound fully dissolved in water, the flame test which had no discoloration when held in the flame, cation and anion tests which showed the existence of some halides like Cl, Br, and I, pH test in which the compound had a pH of 6, and the conductivity test which had an average value…
Lab 4 in Chem 115 has three parts all calculating density. In part one, a 100 mL beaker, a volumetric pipet, and an analytical scale were obtained. To begin, the mass of the beaker was taken using an analytical scale. Then, 10.0 mL of an unknown liquid was transfered to the beaker using the volumetric pipet. Next, the mass of the beaker and liqiud was recorded along with the letter identifying the unknown liquid.…
In conclusion, this experiment was successful and the product 1-methylcyclohexene was…
This is two week project is to evaluate the stereochemical outcome and facial selectivity of an oxidation-reduction interconversion between 4-tert- butylcyclohexanol and 4-tert-butylcyclohexanone while investigating the stereoselectivity of different reducing agents. During the first week, 4-tert-butylcyclohexanol, a secondary alcohol (mixture of cis and trans stereoisomers) is to be oxidized into a ketone, 4-tert-butylcyclohexanone using sodium hypochlorite (bleach). Thin layer chromatography (TLC) is used to monitor the progress of the the reaction. The second week of the reaction, 4-tert-butylcyclohexanone is reduced using sodium borohydride or the Meerwein-Pondorff-Verley (MPV) conditions. NMR spectroscopy is used to evaluate the stereochemical…
Thirdly, the impurities and acetanilide crystals must be separated. Therefore, the solution must be cooled, thus the solubility of the compound will decrease, and the compound will precipitate. Indeed, the solution must be cooled slowly – from room temperature then to an ice bath –, as a drastic decrease in temperature would cause the compound to precipitate too fast, thus impurities to be trapped within the crystals structure. Therefore, the compound will precipitate and be separated from the impurities, which will remain dissolved in the solution.…
In this lab, we carried out a variety of reactions using different chemicals and metals. A chemical reaction is when the chemical state of the substance you are testing rearranges its ionic and molecular structure. One of the reactions we experienced was single replacement, this consists of one ion switching places with another ion to form a new compound. Another reaction we saw was double replacement. In this reaction, two compounds ions are switched to form two new compounds.…
In this equation, x and y denotes the number of moles of RE and Mn atoms per formula unit of the structure, respectively. The RE and Mn represent the theoretical magnetic moment of trivalent free RE3+ ions and divalent Mn2+ ions respectively. The experimental values of total magnetic moments were found to be smaller than the calculated values (Table xyz). The crystal field effects can lead to lower value of magnetic moments for RE3+ ions in these compositions as compared to free RE3+ ions, which in turn could lower the total magnetic moment of these compositions. This discrepancy in the total magnetic moment values could also be due to the presence of secondary phases in these samples.…
The dehydration of Cyclohexanol requires going through an acid-catalyzed elimination of water for the synthesis of cyclohexane from cyclohexanol. To get cyclohexane from cyclohexanol you must remove the cycloalkane with fractional distillation, drying with anhydrous sodium sulfate, and analyzed by GC data and the bromine test. The reaction we are trying to accomplish going from cyclohexanol to cyclohexene is a secondary alcohol going through an E1 reaction. This is the unimolecular elimination reaction in which Zaitsev’s rule applies where the most substituted alkene is formed.…
Chloro(pyridine)cobaloxime – Molar Mass = 403.71gmol-1 Theoretical Yield = 21.8558665mmol 21.8558665mmol*403.71gmol-1 = 8.823431865g [2.671g / 8.823431865g]*[100/1] = 30.271668% Percentage Yield ≈ 30% B) Chloro(pyridine)cobaloxime + MeI Methyl(pyridine)cobaloxime Ratio of reactants to products:…
Benzocaine was synthesized from p-toluidine in a four step synthesis. Each intermediate product, including N-acetyl-p-toluidine, p-acetamidobenzoic acid, and p-aminobenzoic acid, was checked for yield, presence, and purity through weighing, taking IR and NMR spectrums, and determining the melting point. Thin Layer Chromatography was used to ensure the completion of the final reaction from p-aminobenzoic acid to benzocaine. The yield of the first step from p-toluidine to N-acetyl-p-toluidine was 91.9%. The yield of the second step from N-acetyl-p-toluidine to p-acetamidobenzoic acid was 49.85% The yield of the third step from p-acetamidobenzoic acid to p-aminobenzoic acid was 32.49%, which was not enough to continue so some product was borrowed…
The Schiff base compound prepared from condensation reaction…
A possible chemical reason that this experiment yielded less than 100% triphenylcarbinol was caused by the Grignard reagent reacting with atmospheric water or oxygen instead of reacting with benzophenone due to the highly reactive nature of the Grignard reagent and a constant presence of humidity and moisture inside the laboratory. Although extra precautions were taken to dry to glassware and a CaCl2 drying tube was used, there was an unavoidable exposure of the Grignard reagent to atmospheric oxygen and water due to the operating conditions within the laboratory, especially occurring after each time the drying tube was removed to add additional solvents or reagents. The Grignard reagent could have reacted with atmospheric water to protonate…