Agents: Description of clinical signs fit description of cholinergic toxidrome due to the inhibition of acetylcholinesterase, which has effects on both the peripheral and central nervous system. Nerve agents including: Tabun (GA), Soman (GD), Sarin (GB), GF and VX. carbamate pesticide (aldicarb), organophosphate pesticides including: parathion and malathion, hydrogen cyanide
Vapor or aerosal(mg ⋅ min/m3)
Tabun (GA): LCt50: 400, Sarin (GB): LCt50: 100, Soman (GD): LCt 50: 50, VX: LCt50: 10, Cyanide: 100-300 ppm
Liquid (mg) through skin absorption Tabun (GA): LD50: 1000, Sarin (GB): LD50: 1700, Soman (GD) LD50: 100, VX: LD50: 10, Cyanide: 100mg/kg
State of the Agent: Vapor, liquid
Body Sites: Inhalation, ingestion (liquid), dermal (skin, eyes, nasal passages, mucous membranes) …show more content…
By preventing this breakdown, acetylcholine accumulates and continuously binds to both nicotinic and muscarinic receptors found throughout the body. Local effects occur with vapor exposure to the face with mild inhalation and include symptoms of miosis, lacrimation, salivation, rhinorrhea, bronchoconstriction and excessive upper airway and bronchial secretions. Systemic effects caused by moderate to severe inhalation exposure include gastrointestinal effects (i.e. abdominal cramping, nausea, vomiting, and diarrhea), skeletal muscle effects (i.e. fasciculations, restlessness, weakness, paralysis) and CNS effects (i.e. loss of consciousness, seizures, coma, and central
Vapor or aerosal(mg ⋅ min/m3)
Tabun (GA): LCt50: 400, Sarin (GB): LCt50: 100, Soman (GD): LCt 50: 50, VX: LCt50: 10, Cyanide: 100-300 ppm
Liquid (mg) through skin absorption Tabun (GA): LD50: 1000, Sarin (GB): LD50: 1700, Soman (GD) LD50: 100, VX: LD50: 10, Cyanide: 100mg/kg
State of the Agent: Vapor, liquid
Body Sites: Inhalation, ingestion (liquid), dermal (skin, eyes, nasal passages, mucous membranes) …show more content…
By preventing this breakdown, acetylcholine accumulates and continuously binds to both nicotinic and muscarinic receptors found throughout the body. Local effects occur with vapor exposure to the face with mild inhalation and include symptoms of miosis, lacrimation, salivation, rhinorrhea, bronchoconstriction and excessive upper airway and bronchial secretions. Systemic effects caused by moderate to severe inhalation exposure include gastrointestinal effects (i.e. abdominal cramping, nausea, vomiting, and diarrhea), skeletal muscle effects (i.e. fasciculations, restlessness, weakness, paralysis) and CNS effects (i.e. loss of consciousness, seizures, coma, and central