Etiopathogenesis
Crohn’s has a couple of genes that contributes to its existence. The most know gene is the NOD2/CARD15 “nucleotide-binding oligomerization domain containing 2” that is located on chromosome 16.This chromosomes main function is to help the body attack foreign invaders, it identifies the virus or bacteria and initiates the auto immune system to respond to the invasion. Mutations to this chromosome can increase the chances for a person to get Crohn’s disease, more than 40 variations been found in association to the disease [14].The most known variation of the NOD2 is 3020insC or 1007fs , which makes the gene shorter than original. It is unclear how this variation can increase the risk of Crohn’s disease but it’s believed that when it mutates it stops recognizing the bacteria. The bacteria then grows and eventually invade the cells in the intestines that causes inflammation and occurrence of the disease [15].
The second known gene that can contribute to Crohn’s disease is the DLG5 that is located on chromosome 10 known as “chromosome 10 open reading frame 2” C10orf2 is its symbol [16]. This gene is responsible to give instructions to …show more content…
This diet is not to lose weight rather help to reduce inflammations, usually a malnutrition occurs with the disease. Patients with low level of inflammation need a basic diet that consists of simple sugars and amino acids that do not need digestion, this diet modifies the intestinal content and relief some of the inflammation. An advanced patient needs a complex diet; this includes carbohydrates; because half of his calories come from them. Complex carbohydrates include fruits and whole grains as well as vegetables. The patient should drink many fluids especially water; caffeine should be avoided, it showed some correlation to inflammations. The diet should also contain omega3 fatty acids; these
Crohn’s has a couple of genes that contributes to its existence. The most know gene is the NOD2/CARD15 “nucleotide-binding oligomerization domain containing 2” that is located on chromosome 16.This chromosomes main function is to help the body attack foreign invaders, it identifies the virus or bacteria and initiates the auto immune system to respond to the invasion. Mutations to this chromosome can increase the chances for a person to get Crohn’s disease, more than 40 variations been found in association to the disease [14].The most known variation of the NOD2 is 3020insC or 1007fs , which makes the gene shorter than original. It is unclear how this variation can increase the risk of Crohn’s disease but it’s believed that when it mutates it stops recognizing the bacteria. The bacteria then grows and eventually invade the cells in the intestines that causes inflammation and occurrence of the disease [15].
The second known gene that can contribute to Crohn’s disease is the DLG5 that is located on chromosome 10 known as “chromosome 10 open reading frame 2” C10orf2 is its symbol [16]. This gene is responsible to give instructions to …show more content…
This diet is not to lose weight rather help to reduce inflammations, usually a malnutrition occurs with the disease. Patients with low level of inflammation need a basic diet that consists of simple sugars and amino acids that do not need digestion, this diet modifies the intestinal content and relief some of the inflammation. An advanced patient needs a complex diet; this includes carbohydrates; because half of his calories come from them. Complex carbohydrates include fruits and whole grains as well as vegetables. The patient should drink many fluids especially water; caffeine should be avoided, it showed some correlation to inflammations. The diet should also contain omega3 fatty acids; these