The effects infused crystalloid fluid has on osmotic pressures and total protein on horses undergoing surgery for colic
Ashleigh Dawson
815672
31 October 2016
ABSTRACT
Background: Horses diagnosed with colic can present with hypovolemia and dehydration if not infused with crystalloid fluid during surgery. The maintenance of colloid osmotic pressure (COP) and total protein (TP) is necessary to avoid intra- and post-operative complications.
Methods: Twenty nine horses being treated for colic underwent surgery. The horses received IV Xylazine before being anaesthetised, followed by a variety of drugs as required. Lactated Ringer’s saline solution was administered throughout surgery and the volume was recorded throughout surgery. Blood …show more content…
A Pearson correlation showing the linear relationship between measured TP and the measured COP for pre-induction, induction, 30, 60, 90, 120 and 150 minute intervals.
Prior to anaesthetic induction COP and TP were 18.5 ± 2.4 mmHg and 6.3 ± 0.8 g/dL respectively (Fig 1). Immediately upon induction both decreased to 17.0 ± 2.2 mmHg and 5.9 ± 0.8 g/dL (p < 0.05) (Table 1). After 60 minutes after induction, both values had further decreased to 14.5 ± 2.2 mmHg and 5.2 ± 0.7 g/dL (p < 0.05). Until the surgery was complete, COP and TP tended to decrease linearly (Fig 2). An R2 = 0.893 indicates a strong correlation between COP and TP. When the surgery was almost complete at 150 minutes, COP and TP were measured to be 11.6 ± 1.8 mmHg and 4.5 ± 0.5 g/dL respectively.
Table 1. Paired two-sample t-tests comparing COP at pre-induction to specific time periods during surgery. All results show a significant difference (p < 0.05). Calculating colloid osmotic pressure
All values from 171 TP measurements at pre-induction, induction, 30, 60, 90, 120 and 150 minute intervals were used and converted to obtain calculated COP measurements.
Figure 3. A Pearson correlation showing the relationship between measured COP and calculated COP using all intervals. The Line of Agreement is shown in …show more content…
2007). General anaesthesia is known to be linked to hypotension, dehydration and ultimately oedema (Wendt-Hornickle et al. 2011). During surgery, it is necessary to sustain sufficient intravascular volume in order to ensure adequate tissue perfusion occurs (reference, orig data). The general therapy practised by veterinarians is to administer large volumes of crystalloid fluid in an attempt to reduce anaesthetic-related complications by maintaining or increasing intravascular volume (Wagner, 2008). Colloid osmotic pressure (COP) is a critical factor that regulates the distribution of fluids into tertiary spaces (Boscan et al.
Ashleigh Dawson
815672
31 October 2016
ABSTRACT
Background: Horses diagnosed with colic can present with hypovolemia and dehydration if not infused with crystalloid fluid during surgery. The maintenance of colloid osmotic pressure (COP) and total protein (TP) is necessary to avoid intra- and post-operative complications.
Methods: Twenty nine horses being treated for colic underwent surgery. The horses received IV Xylazine before being anaesthetised, followed by a variety of drugs as required. Lactated Ringer’s saline solution was administered throughout surgery and the volume was recorded throughout surgery. Blood …show more content…
A Pearson correlation showing the linear relationship between measured TP and the measured COP for pre-induction, induction, 30, 60, 90, 120 and 150 minute intervals.
Prior to anaesthetic induction COP and TP were 18.5 ± 2.4 mmHg and 6.3 ± 0.8 g/dL respectively (Fig 1). Immediately upon induction both decreased to 17.0 ± 2.2 mmHg and 5.9 ± 0.8 g/dL (p < 0.05) (Table 1). After 60 minutes after induction, both values had further decreased to 14.5 ± 2.2 mmHg and 5.2 ± 0.7 g/dL (p < 0.05). Until the surgery was complete, COP and TP tended to decrease linearly (Fig 2). An R2 = 0.893 indicates a strong correlation between COP and TP. When the surgery was almost complete at 150 minutes, COP and TP were measured to be 11.6 ± 1.8 mmHg and 4.5 ± 0.5 g/dL respectively.
Table 1. Paired two-sample t-tests comparing COP at pre-induction to specific time periods during surgery. All results show a significant difference (p < 0.05). Calculating colloid osmotic pressure
All values from 171 TP measurements at pre-induction, induction, 30, 60, 90, 120 and 150 minute intervals were used and converted to obtain calculated COP measurements.
Figure 3. A Pearson correlation showing the relationship between measured COP and calculated COP using all intervals. The Line of Agreement is shown in …show more content…
2007). General anaesthesia is known to be linked to hypotension, dehydration and ultimately oedema (Wendt-Hornickle et al. 2011). During surgery, it is necessary to sustain sufficient intravascular volume in order to ensure adequate tissue perfusion occurs (reference, orig data). The general therapy practised by veterinarians is to administer large volumes of crystalloid fluid in an attempt to reduce anaesthetic-related complications by maintaining or increasing intravascular volume (Wagner, 2008). Colloid osmotic pressure (COP) is a critical factor that regulates the distribution of fluids into tertiary spaces (Boscan et al.