Chronic myeloid leukemia or chronic myelogenous leukemia (CML) is the cancer of myeloid or white blood cells (WBC).
• CML causes an overproduction of mature, in some cases defective, WBC and platelets. This overproduction can cause splenomegaly and fever. Hepatomegaly and weight loss caused by an increase in metabolism.
• CML is a rare form of cancer accounting for 0.5% of all cancer cases. CML is diagnosed in 2 of every 100,000 persons, and it is more prominent in men than women.
• There are three phases: chronic, accelerated and blast crisis. Depending on a number of blast cells in the blood and bone marrow, they are staged accordingly. Chronic 5%, accelerated 10%, and crisis 20% or more. Most people are diagnosed in the chronic phase.
Abnormalities are caused by reciprocal translocation of genes found on chromosomes 9 and 22. The ABL gene found on chromosome 9 is translocated onto chromosome 22 where the BCR gene is located. The BCR gene found on chromosome 22. The combination of the BCR- ABL gene creates …show more content…
The activation of the pathway RAS and JAK pathway also results in the decrease p53 production. o P53 is a tumor protein that regulates the cell cycle. Suppression of this protein causes abnormalities in the cell cycle and thus abnormal growth. Decreased p53 is a hallmark of any cancer which results in the formation of tumors and abnormal growth.
Treatment of CML varies from phase to phase.
There is a variety of medication that can be taken to reduce the number of WBC. Some of these medications include hydroxyurea, interferon alpha, Sprycel, and imatinib. The most prescribed of these medications is imatinib and Sprycel. Both of these drugs act as tyrosine kinases blocker. This medication coupled with allogeneic stem cell transplant helps reduce the abnormal the dividing and production of WBC and
• CML causes an overproduction of mature, in some cases defective, WBC and platelets. This overproduction can cause splenomegaly and fever. Hepatomegaly and weight loss caused by an increase in metabolism.
• CML is a rare form of cancer accounting for 0.5% of all cancer cases. CML is diagnosed in 2 of every 100,000 persons, and it is more prominent in men than women.
• There are three phases: chronic, accelerated and blast crisis. Depending on a number of blast cells in the blood and bone marrow, they are staged accordingly. Chronic 5%, accelerated 10%, and crisis 20% or more. Most people are diagnosed in the chronic phase.
Abnormalities are caused by reciprocal translocation of genes found on chromosomes 9 and 22. The ABL gene found on chromosome 9 is translocated onto chromosome 22 where the BCR gene is located. The BCR gene found on chromosome 22. The combination of the BCR- ABL gene creates …show more content…
The activation of the pathway RAS and JAK pathway also results in the decrease p53 production. o P53 is a tumor protein that regulates the cell cycle. Suppression of this protein causes abnormalities in the cell cycle and thus abnormal growth. Decreased p53 is a hallmark of any cancer which results in the formation of tumors and abnormal growth.
Treatment of CML varies from phase to phase.
There is a variety of medication that can be taken to reduce the number of WBC. Some of these medications include hydroxyurea, interferon alpha, Sprycel, and imatinib. The most prescribed of these medications is imatinib and Sprycel. Both of these drugs act as tyrosine kinases blocker. This medication coupled with allogeneic stem cell transplant helps reduce the abnormal the dividing and production of WBC and