Homework 4
1. A. Hcd19Tg is Human CD-19-Transgenic mice overexpressing CD19 which is a B-lymphocyte antigen present on all B cells. It is a transgenic model of human gene CD-19 introduced into the mice for research studying the effect of CD19 related to B-cell related immunological response
B. CD1dloCD5+ is a rare phenotype of Regulatory B cells found in spleen of normal and autoimmune mice producing IL-10 and hence also called the B10 cells. As this phenotype is identifies to regulate T cell dependent inflammatory response, they are researched for role in myasthenia gravis and other neuro inflammatory diseases.
C. Terbutaline is a B2 adrenergic receptor agonist causing vasodilation, smooth muscle relaxation and skeletal muscle contractions. …show more content…
CD86 is a ligand protein on the surface of Antigen presenting cells which binds to CD28 and CTLA4 on T cells for its activation to suppress immunity.
E. 3’IgH Enhancer Region or Regulatory region at 3’ end of Immunoglobulin heavy chain is involved in transcription of IgH gene. Mutations or changes in this region affecting IgH expression is studied due to toxins and diseases.
F.M1 and M2 microglia are two phenotypes of CNS immune cells Microglia present heterogeneously. In neurodegenerative disease like Alzheimer’s and Parkinson’s disease, the inflammatory response is activated by microglial cells with M1 cells activating proinflammatory response and M2 activating immunosuppressive response and switch among each other in various disease conditions.
G. Suppressor of Cytokine signaling 3 (SOCS3) is a negative feedback protein which inhibit the cytokine signal transduction through the JAK/STAT pathway thereby regulating the cytokine production during infection or autoimmune disease.
H. Cre floxed mice have Lox sites added to its transgene so that the enzyme Cre recombinase which is specific to Lox can identify the Lox coupled DNA sequence and flank them. This model is used for causing knockouts or mutations in target gene of
1. A. Hcd19Tg is Human CD-19-Transgenic mice overexpressing CD19 which is a B-lymphocyte antigen present on all B cells. It is a transgenic model of human gene CD-19 introduced into the mice for research studying the effect of CD19 related to B-cell related immunological response
B. CD1dloCD5+ is a rare phenotype of Regulatory B cells found in spleen of normal and autoimmune mice producing IL-10 and hence also called the B10 cells. As this phenotype is identifies to regulate T cell dependent inflammatory response, they are researched for role in myasthenia gravis and other neuro inflammatory diseases.
C. Terbutaline is a B2 adrenergic receptor agonist causing vasodilation, smooth muscle relaxation and skeletal muscle contractions. …show more content…
CD86 is a ligand protein on the surface of Antigen presenting cells which binds to CD28 and CTLA4 on T cells for its activation to suppress immunity.
E. 3’IgH Enhancer Region or Regulatory region at 3’ end of Immunoglobulin heavy chain is involved in transcription of IgH gene. Mutations or changes in this region affecting IgH expression is studied due to toxins and diseases.
F.M1 and M2 microglia are two phenotypes of CNS immune cells Microglia present heterogeneously. In neurodegenerative disease like Alzheimer’s and Parkinson’s disease, the inflammatory response is activated by microglial cells with M1 cells activating proinflammatory response and M2 activating immunosuppressive response and switch among each other in various disease conditions.
G. Suppressor of Cytokine signaling 3 (SOCS3) is a negative feedback protein which inhibit the cytokine signal transduction through the JAK/STAT pathway thereby regulating the cytokine production during infection or autoimmune disease.
H. Cre floxed mice have Lox sites added to its transgene so that the enzyme Cre recombinase which is specific to Lox can identify the Lox coupled DNA sequence and flank them. This model is used for causing knockouts or mutations in target gene of