Hutchinson-Gilford Progeria Syndrome (HGPS) is a lethal congenital disorder, characterised by premature appearance of expedited senescent in children.Approximately 90% of HGPS patients have an identical mutation in paternal allele of the LMNA gene – a supersession of cytosine to thymine at nucleotide. Albeit ostensibly a silent mutation (that is, no transmutation in the amino acid, G608G), it causes aberrant mRNA splicing, which leads to the engenderment of a truncated and partially processed pre-lamin A protein called “progerin”. Accumulation of progerin is thought to underlie the pathophysiology of HGPS. Individuals with HGPS appear to show senescent-cognate phenotypes at a much more expeditious rate than mundane, consequently leaving adolescent
