Burkitt lymphoma (BL) is an uncommon form of non-Hodgkin lymphoma (NHL), it is a cancer which affects a type of white blood cells called lymphocytes in the lymphatic system. There are three main types of BL (endemic, sporadic and immunodeficiency related). The endemic type of Burkitt’s lymphoma is considerably more common in sub-Saharan Africa, in where it has a close link to Epstein - Barr virus (EBV) and Malaria, whereas the sporadic type only has a 20% association with the EB virus and is commonly seen in Europe and Northern America. (Lutchman and Stefan, 2014). The immunodeficiency-associated Burkitt’s lymphoma is commonly associated with HIV and AIDS patients, it can also occur in patients in after transplant and they are taking immunosuppressive
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(EPOCH (chemotherapy), 2015). This is often combined with rituximab which can be called R-EPOCH. Rituximab is a chimeric monoclonal antibody against the protein CD20 which is mostly found on the surface of immune system B cells. (Rituximab, 2015)
Prognosis of Burkitt lymphoma (BL) in children, depends on the bulk of the disease at the time of diagnosis, Intensive systematic chemotherapy is the ideal choice of treatment for BL, which means the boy will be staying at hospital for a few weeks, he can also be given a monoclonal antibody drug called rituximab alongside the chemotherapy, but the combination of drugs that the boy will receive depend on the stage of lymphoma he is at and if he can bare the side effects.
The drugs that the boy will receive will be given to him intravenously, some of the drugs that will be given to him are: cyclophosphamide, vincristine, doxorubicin, methotrexate and cytarabine, chemotherapy can also be given through into the spinal fluid to reach the spinal cord and central nervous system. This is either done to prevent the lymphoma cells from spreading into the cerebrospinal
(EPOCH (chemotherapy), 2015). This is often combined with rituximab which can be called R-EPOCH. Rituximab is a chimeric monoclonal antibody against the protein CD20 which is mostly found on the surface of immune system B cells. (Rituximab, 2015)
Prognosis of Burkitt lymphoma (BL) in children, depends on the bulk of the disease at the time of diagnosis, Intensive systematic chemotherapy is the ideal choice of treatment for BL, which means the boy will be staying at hospital for a few weeks, he can also be given a monoclonal antibody drug called rituximab alongside the chemotherapy, but the combination of drugs that the boy will receive depend on the stage of lymphoma he is at and if he can bare the side effects.
The drugs that the boy will receive will be given to him intravenously, some of the drugs that will be given to him are: cyclophosphamide, vincristine, doxorubicin, methotrexate and cytarabine, chemotherapy can also be given through into the spinal fluid to reach the spinal cord and central nervous system. This is either done to prevent the lymphoma cells from spreading into the cerebrospinal