Bone Formation Research Paper

Intramembranous bone formation, also known as ossification, is how flat bones develop from mesenchyme tissue. In this method of bone formation, there are four major steps in the developing process. In the first step, the ossification center forms by osteoblasts. These osteoblasts are created from stem cells within the mesenchyme that specialize. In the second step the osteoblasts from the ossification center produce proteins make up the osteoid. After the osteoid if formed it will combine with calcium and make a calcified bone. After the calcified bone is created it will engulf osteoblasts turning them into osteocytes. In the third step, the osteoid is laid down around different blood vessels and trabeculae form around those vessels forming …show more content…
The osteoid condenses and forms compact bone. The flat bones of the skull are formed by intramembranous ossification. The Endochondral method of bone formation is composed of five steps and uses hyaline cartilage as a model to form long bones. The first step of endochondral ossification is the collar formation. Periosteum form around hyaline cartilage then stem cells specialize into osteoblasts. Much like the intramembranous ossification process, the osteoblasts produce proteins, however these proteins are located on on the outside of the cartilage forming a bony collar. In the second step, the center hardens and makes inner cartilage deteriorate while cavities start to form. In the third step the vessels from the periosteum passes through the collar and invades the inner cavity of the cartilage model. In the fourth step, the bone starts to elongate because of the elongation, the medullary cavity is formed. In the fifth step, the spongy bone is formed in a similar way that the compact bone is formed in step three. At the end of the formation hyaline carriage is left on the ends of the bones and epiphyseal plates