Craniofacial defects such as cleft lip and cleft palate which occur as an isolated condition, or may be one component of an inherited disease or syndrome are among the most common of all birth defects. Cleft lips and palates are frequent congenital craniofacial malformations, with an incidence of 1.5-2.5 per 1,000 live births. Children who have an orofacial cleft require several surgical procedures. Most large defects, also known as critical bone defects are successfully treated with allogenous as well autogenous bone grafts. From these treatment options, autogenous bone graft is gold standard to treat critical size bone defects. However, this treatment has significant amount of limitations in terms of donor morbidity, immune rejection, bone
