Throughout the development of atherosclerotic plaque, it happens smooth muscle cells (SMC) migration of tunica media to the tunica intima of arteries, which induces extracellular matrix production that make portions of the fibrous atherosclerotic plaque cap. Under the fibrous cap, there is a necrotic center including lipids and cellular debris, abandoned as an outcome of foam cells deaths. The atherosclerotic plaque develops gradually, then sometimes, may completely block the artery. This process is mediated by cytokines and growth factors that are secreted by tissue macrophages, permitting the progress of atheromatous lesions in their mature form (3, 7).
