Atherosclerotic Case Studies

During past three decades efforts have been put to reduce the cardiovascular risk factors so that the coronary mortality rate will decrease (1). Although, scientists have reached to advances in this field, but the probability of occurring an ischemic event is still noticeable in patients who follow guildline-base approaches to cardiovascular prevention (2). Since the overall rate of atherosclerotic disease is increasing worldwide, cardiovascular disease is now consider as a global cause of death. Therefore, more significant approaches are needed to reduce the occurrence of acute ischemia.
Previous studies has clarified the role of inflammation in mature atherosclerosis plaque rupture and acute ischemia (3). This suggests that targeting specific …show more content…
The curcumin`s beneficial effects on various inflammatory and degenerative diseases (e.g. Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsy, cerebral injury, cardiovascular disease, cancer, allergy, asthma, bronchitis, colitis, rheumatoid arthritis, renal ischemia, psoriasis, diabetes, obesity, depression, fatigue and AIDS) have been well established(8-11). Although curcumin doesn’t seem to be toxic to animal and human, but its bioavailability is poor (12, 13). Curcumin moderates several inflammatory factors in cardiac tissue including: NF-κB, CRP, AP-1, myeloperoxidase enzyme (MPO), MMP-9. Il-1, Il-6, IL-8, IL-10, monocyte chemoattractant proteine-1 (MCP-1) and TNF-α in cardiovascular tissues (14). These mediators are the main cause of plaque rupture and ACS. Also literature suggests the protective role of curcumin in hyperlipidemia and myocardial infarction (15, 16).
Regarding that the role of inflammatory mediators is now clear in plaque rapture and that the present secondary preventions are not ideal, this study is set up to suggests curcumin as a secondary prevention for ACS considering its plaque stabilizing