General procedure: One equivalent of spacer was coupled using 2.4 equivalents of inhibitor, 0.18 equivalents of copper sulfate, 0.36 equivalents of (+)-sodium-L-ascorbate, in a mixture of 10% H2O in DMF, 24 mL/mmol spacer. The mixture was placed in the microwave for 30 minutes at 80oC
Pro6 Spacer (10) (30 mg, 0.036 mmol) and 18 (36 mg, 0.087 mmol) were dissolved in 778 µL DMF. Copper sulfate (1.62 mg, 0.006 mmol) and sodium-L- ascorbate (2.57 mg, 0.013 mmol) were dissolved in 86 µL H2O. The two solutions were combined in a microwave tube and put in the microwave for 30 minutes at 80oC. The solvent was evaporated under reduced pressure.…