Angiotensin Converting Enzyme Inhibitors Lab Report

Introduction of Angiotensin-Converting Enzyme Inhibitors
LeMone & Burke (2011) stated that in other to accurately discuss angiotensin converting enzyme inhibitors, it is very important to first of all briefly discuss about the three forms of angiotensin. Angiotensin I is produced by the action of renin on a protein called angiotensinogen, which is formed by the liver. Angiotensin I is then transformed into angiotensin II in the blood by the action of angiotensin-converting enzyme ACE. Angiotensin II therefore causes contraction of the muscle surrounding the blood vessels that leads to the narrowing of the vessels. When this process occurred (narrowing of the vessels) it causes the pressure within the vessels to increase which leads to hypertension, elevation of blood pressure. …show more content…
This collection of drugs causes the blood vessels to relax, and at the same time reduced blood volume and as a result, blood vessels are dilated and blood pressure is reduced. This reduced blood pressure helps the heart to pump blood easily, it decreases oxygen demand on the heart, and improves the function of a failing heart. Furthermore, the progression of diabetes or kidney disease due to hypertension will also slowed down. In addition, angiotensin-converting enzyme is also responsible for the breaking down of bradykinin. Bryant & Knight (2007, p.299) continue by saying Therefore, because angiotensin-converting inhibitors blocks the breakdown of bradykinin, it increase the levels of bradykinin, which can contribute to the vasodilator action of angiotensin converting enzyme inhibitors. The increasing in the level of bradykinin is also believed to be accountable for a problematic side effect of angiotensin-converting enzyme inhibitors like a dry