Adenosine triphosphatase (ATPase) is a mitochondrial lipid dependent membrane bound enzyme and principle donor of free energy in the living system. Any alteration in membrane lipids leads to changes in membrane fluidity, which in turn alters the ATPase activity and cellular function. The use of ATPase level measurement was considered as an appropriate index of membrane damage. Pathological processes that interfere with the production of ATP may interfere with sodium pump activity, which in turn results in decreased cellular function. The cellular sites for free radical generation include mitochondria, endoplasmic reticulum and plasma membrane. It has been hypothesized that oxidative damage of membrane bound ATPase activity is crucial for mitochondrial
