Acute Pancreatitis Research Papers

Acute pancreatitis is a sudden, but reversible inflammatory process of the pancreas. The most common cause of pancreatitis is alcohol in western countries and gallstone in eastern countries. Approximately 80% patients have mild pancreatitis and 20% of patients have severe pancreatitis. About 15-25% of acute pancreatitis develops into severe pancreatitis. Mild pancreatitis has mortality rate less 1% (1, 2) where as the mortality rate of severe pancreatitis varies from (10-30) % depending upon sterile or necrotic infection (3). The Atlanta classification reported on 1992 (4) is the most widely accepted classification system for the severity of pancreatitis. It divides acute pancreatitis into mild and severe types. Acute pancreatitis without parenchymal necrosis such as interstitial or edematous is called mild pancreatitis. Severe acute pancreatitis (SAP) is defined by following four criteria: …show more content…
Organ failure of one or more of the following; shock (systolic blood pressure < 90mm Hg), renal failure (serum creatinine>177 μmol/l or 2mg/dl after rehydration), pulmonary insufficiency (pao2500ml in 24 hours);
2. Local pancreatic complications such as pseudocyst, abscess or necrosis;
3. A score of 3 or more on Ranson’s criteria;
4. A score of 8 or more on acute physiology and chronic health evaluation II (APACHE II).
Patients must meet one or more of the above four criteria to be called as Severe acute pancreatitis (SAP) under Atlanta classification system